Abstract | BACKGROUND: OBJECTIVE: To test the hypothesis that GC single nucleotide polymorphisms encoding the D432E and T436K variants predict subsequent development of asthma in healthy children. METHODS: A retrospective medical record review was performed to determine the development of asthma in 776 children in whom GC genotype, vitamin D-binding protein concentration, and circulating 25-hydroxyvitamin D had been determined at 6 to 36 months of age. Demographic and detailed current clinical data were collected and criteria for asthma were recorded. RESULTS: GC genotype was available for 463 subjects. After an initial analysis of all subject data, the analysis was limited to the predominant Hispanic population (72.1%) to minimize potential confounding effects of ethnicity. Asthma was diagnosed in 87 children (26%). Subjects with the GC genotype encoding the ET/ET (Gc1s/Gc1s) variant had lower odds of developing asthma, representing a protective effect compared with subjects with the DT/DT (Gc1f/Gc1f) variant. CONCLUSION: In the Hispanic population of inner-city New Haven, Connecticut, the ET/ET (Gc1s/Gc1s) genotype of vitamin D-binding protein might confer protection against the development of asthma compared with the wild-type genotype DT/DT (Gc1f/Gc1f).
|
Authors | Aledie Navas-Nazario, Fang Yong Li, Veronika Shabanova, Pnina Weiss, David E C Cole, Thomas O Carpenter, Alia Bazzy-Asaad |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 112
Issue 6
Pg. 519-24
(Jun 2014)
ISSN: 1534-4436 [Electronic] United States |
PMID | 24745702
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Copyright | Copyright © 2014 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Receptors, Calcitriol
- Vitamin D-Binding Protein
- Vitamin D
- 25-hydroxyvitamin D
- Cytochrome P450 Family 2
- CYP2R1 protein, human
- Cholestanetriol 26-Monooxygenase
|
Topics |
- Asthma
(genetics)
- Child, Preschool
- Cholestanetriol 26-Monooxygenase
(genetics)
- Connecticut
- Cytochrome P450 Family 2
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Hispanic or Latino
(genetics)
- Humans
- Infant
- Male
- Polymorphism, Single Nucleotide
- Receptors, Calcitriol
(genetics)
- Retrospective Studies
- Vitamin D
(analogs & derivatives, blood, genetics, therapeutic use)
- Vitamin D-Binding Protein
(blood, genetics)
|