[Incidence of proapoptotic proteins p53 and p21 in epithelial ovarian tumors].

Abstract

OBJECTIVE:

The aim of the study was to evaluate the expression of proapoptotic proteins p53 and p21 in cystadenomas, borderline tumors and ovarian cancers. The correlation between proapoptotic proteins and selected parameters of ovarian tumors was also assessed.

MATERIAL AND METHODS:

The study group consisted of 66 patients operated on because of epithelial ovarian tumor The study group was further divided into three subgroups: cystadenomas, borderline tumors and ovarian cancers.

RESULTS:

The average value of p53 was the highest in the ovarian cancer group (50.12 +/- 39.52), whereas average value for p21 was the highest in patients with borderline tumors (24.41 +/- 24.43). There was a negative correlation between tumor stage and parameters of p21(+++), p21(++), p271 (+) but no correlation was found between the expression of p53, p21 and histological type of ovarian cancer.

CONCLUSION:

The assessment of p53 and p21 can be expensive, but it proves to be a useful tool in difficult cases. Positive reaction to p53 can be noted in both, benign and malignant ovarian tumors, but in case of cancer its intensity is notably stronger.

• Authors: Małgorzata Gajewska, Mirosław Wielgoś, Grzegorz Panek, Janina Marczewska
• Journal: Ginekologia polska (Ginekol Pol) Vol. 85 Issue 2 Pg. 111-6 (Feb 2014) ISSN: 0017-0011 [Print] Poland
• Vernacular Title: Analiza czestości wystepowania proapoptycznych białek p53 i p21 w nabłonkowych guzach jajnika.
• PMID: 24745156 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• CDKN1A protein, human
• Cyclin-Dependent Kinase Inhibitor p21

Topics

• Adult
• Aged
• Biomarkers, Tumor (genetics)
• Carcinoma, Ovarian Epithelial
• Cyclin-Dependent Kinase Inhibitor p21 (genetics)
• Female
• Genes, p53 (genetics)
• Humans
• Immunohistochemistry
• Incidence
• Middle Aged
• Neoplasm Staging
• Neoplasms, Glandular and Epithelial (epidemiology, genetics, pathology)
• Ovarian Neoplasms (epidemiology, genetics, pathology)
• Precancerous Conditions (genetics)