A chemical approach to "rewire" neural progenitor cells.

Abstract	Generation of neural progenitor cells (NPCs) from pluripotent stem cells including ESCs and iPSCs and derivation of NPCs from somatic tissues have been considered promising approaches that could be used therapeutically to restore function in patients suffering neurodegenerative diseases. A new study published in Cell Research shows, for the first time, the generation of NPCs from somatic cells by small molecule compounds under hypoxia without exogenous transcription factors.
Authors	Min-Zu Wu, Mo Li, Guang-Hui Liu, Juan Carlos Izpisua Belmonte
Journal	Cell research (Cell Res) Vol. 24 Issue 6 Pg. 641-2 (Jun 2014) ISSN: 1748-7838 [Electronic] England
PMID	24743789 (Publication Type: Journal Article, Comment)
Chemical References	Chir 99021 Enzyme Inhibitors Pyrazoles Pyridines Pyrimidines RepSox Valproic Acid
Topics	Animals Cell Hypoxia Enzyme Inhibitors (pharmacology) Humans Neural Stem Cells (drug effects) Pyrazoles (pharmacology) Pyridines (pharmacology) Pyrimidines (pharmacology) Valproic Acid (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!