Resolution of pure red cell aplasia and lymphoma: response to intravenous gammaglobulin and combination chemotherapy.

Abstract

Pure red cell aplasia (PRCA) rarely occurs in nonthymic lymphoproliferative disorders. This report describes the clinical course and therapy of a patient with a history of Sjogren syndrome who developed well-differentiated lymphocytic lymphoma associated with PRCA and severe hemolytic anemia. Life-threatening hemolytic anemia combined with the presence of multiple antibodies and lack of erythroid precursors was treated successfully with a single dose of intravenous gammaglobulin. A sustained, complete remission and normalization of the bone marrow was achieved following six courses of an aggressive chemotherapy regimen. Thus, occasionally low-grade lymphomas can produce life-threatening complications, requiring a more aggressive therapeutic intervention than those routinely applied.

• Authors: S J Vukelja, J Krishnan, C M Link, A J Salvado, R D Knight
• Journal: American journal of hematology (Am J Hematol) Vol. 32 Issue 2 Pg. 129-33 (Oct 1989) ISSN: 0361-8609 [Print] United States
• PMID: 2474247 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• gamma-Globulins

Topics

• Anemia, Hemolytic (complications, drug therapy)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Humans
• Injections, Intravenous
• Leukemia, Lymphocytic, Chronic, B-Cell (complications, drug therapy)
• Male
• Middle Aged
• Red-Cell Aplasia, Pure (complications, drug therapy)
• gamma-Globulins (administration & dosage, therapeutic use)