Abstract | BACKGROUND: METHODS: HPV DNA typing of tissue samples and HLA determination from blood samples of four family members were performed by polymerase chain reaction. RESULTS: Histopathological examination of all patients revealed acanthotic papillomatous epidermis, koilocytes, apoptotic keratinocytes, and mitosoid bodies. HPV13 was detected by polymerase chain reaction. HLA DQA1*0501, HLA DQB1*0302, and HLA DRB1*11 alleles were common in all family members. HLA DRB1*04 was detected in three of them. CONCLUSION: This report is the first step for the investigation of involvement of HLA types in the pathogenesis of Turkish patients with FEH.
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Authors | Gülşen Akoğlu, Ahmet Metin, Gülay Güleç Ceylan, Selma Emre, Demet Akpolat, Nuran Süngü |
Journal | International journal of dermatology
(Int J Dermatol)
Vol. 54
Issue 2
Pg. 174-8
(Feb 2015)
ISSN: 1365-4632 [Electronic] England |
PMID | 24738569
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2014 The International Society of Dermatology. |
Chemical References |
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- HLA-DQA1 antigen
- HLA-DQB1 antigen
- HLA-DRB1 Chains
- HLA-DRB1*04 antigen
- HLA-DRB1*11 antigen
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Topics |
- Adolescent
- Adult
- Alleles
- Apoptosis
- Child
- Female
- Focal Epithelial Hyperplasia
(genetics, pathology, virology)
- Genetic Predisposition to Disease
(genetics)
- HLA-DQ alpha-Chains
(genetics)
- HLA-DQ beta-Chains
(genetics)
- HLA-DRB1 Chains
(genetics)
- Humans
- Keratinocytes
(cytology)
- Male
- Papillomaviridae
- Papillomavirus Infections
(complications)
- Turkey
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