Associations of epithelial sodium channel genes with blood pressure changes and hypertension incidence: the GenSalt study.

Abstract

BACKGROUND:

We examined the associations of epithelial sodium channel (ENaC) genes with blood pressure (BP) changes and hypertension incidence in a longitudinal family study.

METHODS:

A total of 2,755 Han Chinese participants of the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) baseline examination were eligible for this study. The associations of 43 tag single nucleotide polymorphisms (SNPs) in ENaC genes with BP changes and hypertension incidence were assessed using mixed models to account for the correlations of repeated measures among individuals and within families. A genotype by time interaction term was used to model differences in longitudinal BP change according to genotype over time. Gene-based analyses were conducted using the truncated product method. The Bonferroni method was used to adjust for multiple testing in all analyses.

RESULTS:

During an average of 7.4 years follow-up, systolic BP (SBP) and diastolic BP (DBP) increased, and approximately 33% of participants developed hypertension. SCNN1A SNP rs11064153 and SCNN1G SNP rs4401050 were significantly associated with longitudinal changes in SBP after adjustment for multiple testing (P interaction = 5.8×10(-4) and 0.001, respectively). Similar but nonsignificant trends were observed for the associations between both rs11064153 and rs4401050 and DBP changes (P interaction = 0.024 and 0.005, respectively) and between rs11604153 and hypertension incidence (P = 0.02). Gene-based analyses also supported the overall association of SCNN1G with longitudinal changes in SBP (P = 2.0×10(-4)).

CONCLUSIONS:

Our findings indicated that SCNN1A and SCNN1G may contribute to BP changes over time in the Han Chinese population. Replication of these findings is warranted.

• Authors: Xueli Yang, Jiang He, Dongfeng Gu, James E Hixson, Jianfeng Huang, Dabeeru C Rao, Lawrence C Shimmin, Jichun Chen, Treva K Rice, Jianxin Li, Karen Schwander, Tanika N Kelly
• Journal: American journal of hypertension (Am J Hypertens) Vol. 27 Issue 11 Pg. 1370-6 (Nov 2014) ISSN: 1941-7225 [Electronic] United States
• PMID: 24735600 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: © American Journal of Hypertension, Ltd 2014. All rights reserved. For Permissions, please email: [email protected].

Chemical References

• Epithelial Sodium Channels
• SCNN1A protein, human
• SCNN1G protein, human

Topics

• Adult
• Aged
• Asian People (genetics)
• Blood Pressure (genetics)
• China (epidemiology)
• Epithelial Sodium Channels (genetics)
• Female
• Genetic Predisposition to Disease
• Humans
• Hypertension (diagnosis, ethnology, genetics, physiopathology)
• Incidence
• Longitudinal Studies
• Male
• Middle Aged
• Phenotype
• Polymorphism, Single Nucleotide
• Risk Factors
• Time Factors