TRP channels and STIM/ORAI proteins: sensors and effectors of cancer and stroma cell migration.

Abstract

UNLABELLED:

Cancer cells are strongly influenced by host cells within the tumour stroma and vice versa. This leads to the development of a tumour microenvironment with distinct physical and chemical properties that are permissive for tumour progression. The ability to migrate plays a central role in this mutual interaction. Migration of cancer cells is considered as a prerequisite for tumour metastasis and the migration of host stromal cells is required for reaching the tumour site. Increasing evidence suggests that transient receptor potential (TRP) channels and STIM/ORAI proteins affect key calcium-dependent mechanisms implicated in both cancer and stroma cell migration. These include, among others, cytoskeletal remodelling, growth factor/cytokine signalling and production, and adaptation to tumour microenvironmental properties such as hypoxia and oxidative stress. In this review, we will summarize the current knowledge regarding TRP channels and STIM/ORAI proteins in cancer and stroma cell migration. We focus on how TRP channel or STIM/ORAI-mediated Ca(2+) signalling directly or indirectly influences cancer and stroma cell migration by affecting the above listed mechanisms.

LINKED ARTICLES:

This article is part of a themed section on Cytoskeleton, Extracellular Matrix, Cell Migration, Wound Healing and Related Topics. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-24.

• Authors: N Nielsen, O Lindemann, A Schwab
• Journal: British journal of pharmacology (Br J Pharmacol) Vol. 171 Issue 24 Pg. 5524-40 (Dec 2014) ISSN: 1476-5381 [Electronic] England
• PMID: 24724725 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2014 The British Pharmacological Society.

Chemical References

• Calcium Channels
• Cytokines
• Intercellular Signaling Peptides and Proteins
• Membrane Proteins
• Neoplasm Proteins
• ORAI1 Protein
• ORAI1 protein, human
• STIM1 protein, human
• Stromal Interaction Molecule 1
• Transient Receptor Potential Channels
• Calcium

Topics

• Adaptation, Physiological
• Calcium (metabolism)
• Calcium Channels (metabolism)
• Cell Movement (physiology)
• Cytokines (metabolism)
• Cytoskeleton (metabolism)
• Humans
• Intercellular Signaling Peptides and Proteins (metabolism)
• Membrane Proteins (metabolism)
• Neoplasm Metastasis
• Neoplasm Proteins (metabolism)
• ORAI1 Protein
• Signal Transduction (physiology)
• Stromal Cells (metabolism, physiology)
• Stromal Interaction Molecule 1
• Transient Receptor Potential Channels (metabolism)
• Tumor Microenvironment (physiology)