Abstract | BACKGROUND: CASE PRESENTATION: A 35-year-old man was consulted for assessment and management of severe hypercalcemia related to an abdominal mass. Nausea, polyuria, polydipsia, lethargy and confusion led him to the emergency department. An abdominal and pelvic enhanced CT confirmed a calcified pelvic mass, along with multiple retroperitoneal lymphadenopathy. Chest x-ray revealed "cannon ball" pulmonary metastases. The histopathology result was consistent with a seminoma. Serum calcium was 14.7 mg/dl, PTH was undetectable, 25-dihydroxyvitamin D was within normal values and PTHrP and 1,25-dihydroxyvitamin were elevated (35.0 pg/ml, and 212 pg/ml, respectively). After the first cycle of chemotherapy with bleomycin, etoposide and cisplatin, normocalcemia was restored. Both PTHrP and 1,25-dihydroxyvitamin D, dropped dramatically to 9.0 pg/ml and 8.0 pg/ml, respectively. CONCLUSION:
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Authors | René Rodríguez-Gutiérrez, Maria Azucena Zapata-Rivera, Dania Lizeth Quintanilla-Flores, Carlos Rodrigo Camara-Lemarroy, Fernando Javier Lavalle-Gonzalez, José Gerardo González-González, Jesús Zacarías Villarreal-Pérez |
Journal | BMC endocrine disorders
(BMC Endocr Disord)
Vol. 14
Pg. 32
(Apr 10 2014)
ISSN: 1472-6823 [Print] England |
PMID | 24721620
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Parathyroid Hormone
- Parathyroid Hormone-Related Protein
- Vitamin D
- 1,25-dihydroxyvitamin D
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Topics |
- Adult
- Humans
- Hypercalcemia
(blood, etiology, pathology, therapy)
- Lung Neoplasms
(blood, etiology, secondary, therapy)
- Male
- Paraneoplastic Syndromes
(blood, etiology, pathology, therapy)
- Parathyroid Hormone
(blood)
- Parathyroid Hormone-Related Protein
(adverse effects, blood)
- Prognosis
- Seminoma
(blood, complications, pathology)
- Testicular Neoplasms
(blood, complications, pathology)
- Vitamin D
(adverse effects, analogs & derivatives, blood)
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