Abstract |
Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor of the jaws that is more common in the mandible than maxilla and has a female preponderance with a peak incidence in the sixth decade. It is characterized by locally aggressive behavior and has the potential to metastasize. This tumor was recently reported to have a rearrangement of the Ewing sarcoma breakpoint region 1 gene ( EWS RNA-binding protein 1, EWSR1) in 5 of 8 cases tested and of the activating transcription factor 1 gene (ATF1) in 1 case tested. We report a case of CCOC in the premolar area of the mandible in a 59-year-old woman. This case demonstrated the presence of both EWSR1 and ATF1 gene rearrangements by fluorescence in situ hybridization.
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Authors | Aaron E Yancoskie, Chandrika Sreekantaiah, Jessy Jacob, Amanda Rosenberg, Morris Edelman, Cristina R Antonescu, John E Fantasia |
Journal | Oral surgery, oral medicine, oral pathology and oral radiology
(Oral Surg Oral Med Oral Pathol Oral Radiol)
Vol. 118
Issue 4
Pg. e115-8
(Oct 2014)
ISSN: 2212-4411 [Electronic] United States |
PMID | 24721473
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Calmodulin-Binding Proteins
- EWSR1 protein, human
- RNA-Binding Protein EWS
- RNA-Binding Proteins
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Topics |
- Adenocarcinoma, Clear Cell
(diagnosis, genetics, pathology, surgery)
- Biopsy
- Calmodulin-Binding Proteins
(genetics)
- Cone-Beam Computed Tomography
- Diagnosis, Differential
- Diagnostic Imaging
- Female
- Gene Rearrangement
- Humans
- Immunohistochemistry
- In Situ Hybridization, Fluorescence
- Mandibular Neoplasms
(diagnosis, genetics, pathology, surgery)
- Middle Aged
- Odontogenic Tumors
(diagnosis, genetics, pathology, surgery)
- RNA-Binding Protein EWS
- RNA-Binding Proteins
(genetics)
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