Cohort study on the treatment with dapsone 5% gel of mild to moderate inflammatory acne of the face in women.

Abstract

Topical dapsone 5% gel for the treatment of mild to moderate acne has been shown to be effective in randomized controlled studies. A total of 101 adult women with mild to moderate facial inflammatory acne participated in a 12-week cohort study to evaluate the efficacy, tolerability, and safety of dapsone gel 5% in this specific group who often complain of sensitive skin. The women were instructed to apply dapsone 5% gel twice daily after washing their face with a standard noncomedogenic soap-free cleanser. Treatment outcome was evaluated using physician-scored Global Acne Assessment Scale (GAAS) and patient-reported facial skin condition. Ninety-three women completed the study (6 were lost to follow-up and 2 had mild skin irritation). At 12 weeks, significant physician GAAS scores (t55 = 8.85, P = .001) and patient-reported lesion reductions were shown. Treatment success (GAAS 0 or 1) at 12 weeks was achieved in 69.4% (n = 75) of women (t94 = 4.17, P = .001), improving patient-reported quality-of-life aspects. Topical dapsone gel 5% was shown to be safe, minimally irritating, and effective in the treatment of mild to moderate inflammatory facial acne in adult women with sensitive skin.

• Authors: Charles W Lynde, Anneke Andriessen
• Journal: Skinmed (Skinmed) 2014 Jan-Feb Vol. 12 Issue 1 Pg. 15-21 ISSN: 1540-9740 [Print] United States
• PMID: 24720080 (Publication Type: Journal Article)

Chemical References

• Dermatologic Agents
• Gels
• Dapsone

Topics

• Acne Vulgaris (drug therapy, pathology)
• Administration, Cutaneous
• Adolescent
• Adult
• Aged
• Cohort Studies
• Dapsone (administration & dosage, adverse effects, therapeutic use)
• Dermatologic Agents (administration & dosage, adverse effects, therapeutic use)
• Face
• Female
• Follow-Up Studies
• Gels
• Humans
• Inflammation (drug therapy, pathology)
• Middle Aged
• Quality of Life
• Severity of Illness Index
• Treatment Outcome
• Young Adult