Topical
tretinoin has been a standard treatment for
acne vulgaris for more than 4 decades. While
tretinoin has demonstrated proven efficacy in the treatment of
acne lesions, it also is associated with the potential for skin irritation. Newer formulations have been designed to optimize both the
drug concentration and the delivery vehicle with the aim to enable clinicians to provide increasingly effective
acne treatment that minimizes irritation. These
therapies include formulations with varying concentrations of
tretinoin and vehicles that utilize a microsponge delivery system,
hydrogels and micronized
tretinoin, or propolymers. The purpose of this review is to evaluate different formulations and combinations of
tretinoin in the treatment of
acne vulgaris. While these advanced formulations were designed for controlled release of active ingredient, and have the potential to reduce cutaneous irritation relative to standard
tretinoin cream and gel formulations, there is a need for comparative studies to evaluate the relative benefits of each of these advanced
tretinoin formulations in optimizing
acne treatment.