α-Adducin gene G614T polymorphisms in essential hypertension patients with high low density lipoprotein (LDL) levels.

Abstract

BACKGROUND & OBJECTIVES:

The association between α-adducin gene G614T polymorphism and essential hypertension (EH) is not clear. The present study was carried out to examine a possible association between α-adducin gene G614T mutation and essential hypertension in Chinese population.

METHODS:

A total of 170 patients with essential hypertension (EH group) and 154 normotensive subjects (Control group) were genotyped for the cytoskeletal protein single nucleotide polymorphism G614T of the α-adducin gene by PCR-RFLP technique. Systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), low density lipoprotein (LDL), high-density lipoprotein (HDL), high-sensitivity C-reactive protein (hs-CRP), left atrial diameter (LA DIA), left ventricular diameter (LV DIA) and other parameters were recorded in EH group.

RESULTS:

There was significant association between EH and α-adducin genotypes (P<0.05). GT and TT genotypes in EH group had higher LDL levels as compared to GG carriers (P<0.05). The LDL concentration was significantly elevated in patients with GT and TT genotypes. The LDL levels also differed significantly in male patients with all the three genotypes.

INTERPRETATION & CONCLUSIONS:

A significant association was found between ADD1 gene G614T polymorphism and EH in Chinese patients. Further studies need to be done to confirm these findings in a large sample.

• Authors: Lifang Wang, Bin Zheng, Hongguang Zhao, Peng Du, Aihua Sun, Kouzhen Hua, Yuyu Gao
• Journal: The Indian journal of medical research (Indian J Med Res) Vol. 139 Issue 2 Pg. 273-8 (Feb 2014) ISSN: 0971-5916 [Print] India
• PMID: 24718403 (Publication Type: Journal Article)

Chemical References

• Calmodulin-Binding Proteins
• Lipoproteins, LDL
• adducin
• C-Reactive Protein

Topics

• Adult
• Aged
• Blood Pressure
• C-Reactive Protein (metabolism)
• Calmodulin-Binding Proteins (genetics)
• Essential Hypertension
• Female
• Genetic Association Studies
• Humans
• Hypertension (blood, genetics, pathology)
• Lipoproteins, LDL (blood)
• Male
• Middle Aged
• Polymorphism, Single Nucleotide