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α-Adducin gene G614T polymorphisms in essential hypertension patients with high low density lipoprotein (LDL) levels.

AbstractBACKGROUND & OBJECTIVES:
The association between α-adducin gene G614T polymorphism and essential hypertension (EH) is not clear. The present study was carried out to examine a possible association between α-adducin gene G614T mutation and essential hypertension in Chinese population.
METHODS:
A total of 170 patients with essential hypertension (EH group) and 154 normotensive subjects (Control group) were genotyped for the cytoskeletal protein single nucleotide polymorphism G614T of the α-adducin gene by PCR-RFLP technique. Systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), low density lipoprotein (LDL), high-density lipoprotein (HDL), high-sensitivity C-reactive protein (hs-CRP), left atrial diameter (LA DIA), left ventricular diameter (LV DIA) and other parameters were recorded in EH group.
RESULTS:
There was significant association between EH and α-adducin genotypes (P<0.05). GT and TT genotypes in EH group had higher LDL levels as compared to GG carriers (P<0.05). The LDL concentration was significantly elevated in patients with GT and TT genotypes. The LDL levels also differed significantly in male patients with all the three genotypes.
INTERPRETATION & CONCLUSIONS:
A significant association was found between ADD1 gene G614T polymorphism and EH in Chinese patients. Further studies need to be done to confirm these findings in a large sample.
AuthorsLifang Wang, Bin Zheng, Hongguang Zhao, Peng Du, Aihua Sun, Kouzhen Hua, Yuyu Gao
JournalThe Indian journal of medical research (Indian J Med Res) Vol. 139 Issue 2 Pg. 273-8 (Feb 2014) ISSN: 0971-5916 [Print] India
PMID24718403 (Publication Type: Journal Article)
Chemical References
  • Calmodulin-Binding Proteins
  • Lipoproteins, LDL
  • adducin
  • C-Reactive Protein
Topics
  • Adult
  • Aged
  • Blood Pressure
  • C-Reactive Protein (metabolism)
  • Calmodulin-Binding Proteins (genetics)
  • Female
  • Genetic Association Studies
  • Humans
  • Hypertension (blood, genetics, pathology)
  • Lipoproteins, LDL (blood)
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide

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