Two new cytotoxic indole alkaloids from a deep-sea sediment derived metagenomic clone.

Abstract

Two new indole alkaloids, metagenetriindole A (1) and metagenebiindole A (2), were identified from deep-sea sediment metagenomic clone derived Escherichia coli fermentation broth. The structures of new compounds were elucidated by spectroscopic methods. The two new indole alkaloids demonstrated moderately cytotoxic activity against CNE2, Bel7402 and HT1080 cancer cell lines in vitro.

• Authors: Xia Yan, Xi-Xiang Tang, Lin Chen, Zhi-Wei Yi, Mei-Juan Fang, Zhen Wu, Ying-Kun Qiu
• Journal: Marine drugs (Mar Drugs) Vol. 12 Issue 4 Pg. 2156-63 (Apr 08 2014) ISSN: 1660-3397 [Electronic] Switzerland
• PMID: 24717525 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Indole Alkaloids

Topics

• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Cell Line, Tumor
• Cloning, Molecular
• Drug Screening Assays, Antitumor
• Escherichia coli (genetics)
• Fermentation
• Geologic Sediments (microbiology)
• Humans
• Indole Alkaloids (chemistry, isolation & purification, pharmacology)
• Metagenomics