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In vitro assessment of antineoplastic effects of deuterium depleted water.

AbstractBACKGROUND:
In vitro, in vivo and clinical studies have demonstrated anti-cancer effects of deuterium depleted water (DDW). The nature of this agents action, cytotoxic or cytostatic, remains to be elucidated. We here aimed to address the point by examining effects on different cell lines.
MATERIALS AND METHODS:
3-(4, 5-dimethylthiazol- 2-yl)-2, 5-diphenyltetrazolium bromide (MTT) -based cytotoxicity analysis was conducted for human breast, stomach, colon, prostate cancer and glioblastoma multiforme cell lines as well as human dermal fibroblasts. The cell lines were treated with decreasing deuterium concentrations of DDW alone, paclitaxel alone and both. One way analysis of variance (ANOVA) was used for statistical analysis.
RESULTS:
Treatment with different deuterium concentrations of DDW alone did not impose any significant inhibitory effects on growth of cell lines. Paclitaxel significantly decreased the survival fractions of all cell lines. DDW augmented paclitaxel inhibitory effects on breast, prostate, stomach cancer and glioblastoma cell lines, with influence being more pronounced in breast and prostate cases.
CONCLUSIONS:
DDW per se does not appear to have inhibitory effects on the assessed tumor cell lines as well as normal fibroblasts. As an adjuvant, however, DDW augmented inhibitory effects of paclitaxel and thus it could be considered as an adjuvant to conventional anticancer agents in future trials.
AuthorsSaeed Soleyman-Jahi, Kazem Zendehdel, Kambiz Akbarzadeh, Mahnaz Haddadi, Saeid Amanpour, Samad Muhammadnejad
JournalAsian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 15 Issue 5 Pg. 2179-83 ( 2014) ISSN: 2476-762X [Electronic] Thailand
PMID24716953 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Water
  • Deuterium
  • Paclitaxel
Topics
  • Antineoplastic Agents (pharmacology)
  • Cell Line
  • Cell Line, Tumor
  • Deuterium (pharmacology)
  • HCT116 Cells
  • Humans
  • Paclitaxel (pharmacology)
  • Water (pharmacology)

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