HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A case of CD138-/CD19+/CD4+ IgD plasma cell leukemia.

AbstractBACKGROUND:
Plasma cell leukemia (PCL) is an uncommon and aggressive disease caused by the clonal proliferation of atypical plasma cells with phenotypical abnormalities similar to those seen in multiple myeloma (MM), although at different rates. Here, we report a case of IgD PCL with a very unusual CD138-/CD19+/CD4+ phenotype.
METHODS:
Peripheral blood and bone marrow samples from a 37-year-old patient afflicted by an aggressive plasma cell dyscrasia were examined and analyzed by conventional morphology, flow cytometry, and immunohistochemistry.
RESULTS:
Analysis of peripheral blood fulfilled criteria for PCL (more than 20% and more than 2 × 10e9 cells/L). However, flow cytometry and immunohistochemistry phenotyping revealed that the cells were CD138-/CD38+/CD19+/CD4+/CD56-/CD117-.
CONCLUSIONS:
PCL is diagnosed on peripheral blood smear. Immunophenotyping is a tool that can be helpful in diagnosing difficult cases but its atypical findings should not prevent the appropriate PCL diagnosis in clinically and morphologically unquestionable cases. © 2014 International Clinical Cytometry Society.
AuthorsMarc Sorigue, Jordi Juncà, Susanna Gassiot, Fuensanta Millá, José-Luis Mate, Josep Tomàs Navarro
JournalCytometry. Part B, Clinical cytometry (Cytometry B Clin Cytom) Vol. 88 Issue 1 Pg. 69-73 (Jan 2015) ISSN: 1552-4957 [Electronic] United States
PMID24715427 (Publication Type: Case Reports, Journal Article)
Copyright© 2014 Clinical Cytometry Society.
Chemical References
  • Antigens, CD19
  • CD4 Antigens
  • Immunoglobulin D
  • SDC1 protein, human
  • Syndecan-1
Topics
  • Adult
  • Antigens, CD19 (genetics, metabolism)
  • CD4 Antigens (genetics, metabolism)
  • Cell Proliferation
  • Flow Cytometry
  • Gene Expression
  • Humans
  • Immunoglobulin D (genetics, metabolism)
  • Immunohistochemistry
  • Immunophenotyping (methods)
  • Leukemia, Plasma Cell (diagnosis, genetics, metabolism, pathology)
  • Male
  • Phenotype
  • Plasma Cells (metabolism, pathology)
  • Syndecan-1 (deficiency, genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: