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High-density lipoproteins in the prevention of cardiovascular disease: changing the paradigm.

Abstract
High-density-lipoprotein cholesterol (HDL-C) has been identified in population studies as an independent inverse predictor of cardiovascular events. Although the causal nature of this association has been questioned, HDL and its major protein, apolipoprotein (apo)A1, have been shown to prevent and reverse atherosclerosis in animal models. In addition, HDL and apoA1 have several putatively atheroprotective functions, such as the ability to promote efflux of cholesterol from macrophages in the artery wall, inhibit vascular inflammation, and enhance endothelial function. Therefore, HDL-C and apoA1 have been investigated as therapeutic targets for coronary heart disease. However, recent clinical trials with drugs that raise HDL-C, such as niacin and inhibitors of cholesteryl ester transfer protein, have been disappointing. Here, we review the current state of the science regarding HDL as a therapeutic target.
AuthorsS Tuteja, D J Rader
JournalClinical pharmacology and therapeutics (Clin Pharmacol Ther) Vol. 96 Issue 1 Pg. 48-56 (Jul 2014) ISSN: 1532-6535 [Electronic] United States
PMID24713591 (Publication Type: Journal Article, Review)
Chemical References
  • Apolipoprotein A-I
  • Cholesterol Ester Transfer Proteins
  • Cholesterol, HDL
  • Lipoproteins, HDL
  • Cholesterol
Topics
  • Apolipoprotein A-I (metabolism)
  • Biological Transport
  • Cardiovascular Diseases (drug therapy, metabolism)
  • Cholesterol (metabolism)
  • Cholesterol Ester Transfer Proteins (antagonists & inhibitors)
  • Cholesterol, HDL (genetics, metabolism)
  • Humans
  • Lipoproteins, HDL (genetics, metabolism)
  • Molecular Targeted Therapy

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