Anti-inflammatory activity of saponins from quinoa (Chenopodium quinoa Willd.) seeds in lipopolysaccharide-stimulated RAW 264.7 macrophages cells.

Abstract

UNLABELLED:

Quinoa (Chenopodium quinoa Willd.) is a pseudocereal from South Americas that has received increased interest around the world because it is a good source of different nutrients and rich in saponins. However, the saponins in quinoa seeds planted in China were poorly known. We obtained 4 quinoa saponin fractions, Q30, Q50, Q70, and Q90, and 11 saponins were determined by HPLC-MS. Q50 possessed 8 individual saponins and had the highest content of saponins. We further evaluated the anti-inflammatory activity on RAW 264.7 murine macrophage cells of the 4 fractions. The 4 fractions not only dose-dependently decreased the production of inflammatory mediators NO but also inhibited the release of inflammatory cytokines including tumor necrosis factor-α and interleukin-6 in lipopolysaccharide-induced RAW264.7 cells. These results suggest that quinoa saponins may be used as functional food components for prevention and treatment of inflammation.

PRACTICAL APPLICATION:

Our findings demonstrate that saponins from the quinoa have the potential to anti-inflammation by suppressing the release of inflammatory cytokines.

• Authors: Yang Yao, Xiushi Yang, Zhenxing Shi, Guixing Ren
• Journal: Journal of food science (J Food Sci) Vol. 79 Issue 5 Pg. H1018-23 (May 2014) ISSN: 1750-3841 [Electronic] United States
• PMID: 24712559 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 Institute of Food Technologists®

Chemical References

• Anti-Inflammatory Agents
• Cytokines
• Inflammation Mediators
• Interleukin-6
• Lipopolysaccharides
• Saponins
• Tumor Necrosis Factor-alpha
• Nitric Oxide

Topics

• Animals
• Anti-Inflammatory Agents (analysis, pharmacology, therapeutic use)
• Chenopodium quinoa (chemistry)
• China
• Cytokines (metabolism)
• Dose-Response Relationship, Drug
• Functional Food
• Inflammation (drug therapy, metabolism)
• Inflammation Mediators (metabolism)
• Interleukin-6 (metabolism)
• Lipopolysaccharides
• Macrophages (drug effects, metabolism)
• Mice
• Nitric Oxide (metabolism)
• Saponins (analysis, pharmacology, therapeutic use)
• Seeds (chemistry)
• Tumor Necrosis Factor-alpha (metabolism)