Although there are several data suggesting a link between lower
lipids levels and the risk of suicide, there are few data concerning lower
lipids levels in patients with
dissociative disorders (DD). This is the first longitudinal study investigating the evolution of the
lipids levels during a specific 8 weeks of psychodynamic psychotherapy (PP) for patients with DD. 32 patients diagnosed with DD (SCID for DSMIVR) were assessed with Dissociative Experiences Scale (DES), Clinical Global Impression and Improvement Scale and their
lipids levels (total
cholesterol,
triglycerides,
high-density lipoprotein,
low-density lipoprotein and
very low density lipoprotein) were measured at inclusion and after 3 and 8 weeks of PP. 30 patients finished the study. There is a significant positive (p < 0.05) link between lower
lipids levels (total
cholesterol, LDL, triglycerids) and a higher level of dissociation (DES scores) at the beginning and at the end of the study. Interestingly, we found a significant (p = 0.018) positive link between the reduction of the dissociation (DES) and the increase of the
triglycerides levels after 8 weeks of treatment. While lower
lipids seems related to a higher level of dissociation before and after the treatment, an increasing
triglycerides level was observed after 8 weeks of PP in patients with a better outcome. Further studies are needed with larger samples and control groups, in order to confirm these preliminary data. These findings could open the way for hypothesis about the role of
lipids in the pathophysiology of DD and raise the question of the patients with DD receiving antilipidemiants agents.