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Extracellular magnesium and calcium reduce myotonia in isolated ClC-1 chloride channel-inhibited human muscle.

AbstractINTRODUCTION:
Experimental myotonia induced in rat muscle by ClC-1 chloride channel-inhibited has been shown to be related inversely to extracellular concentrations of Mg(2+) and Ca(2+) ([Mg(2+) ]o and [Ca(2+) ]o) within physiological ranges. Because this implicates a role for [Mg(2+)]o and [Ca(2+)]o in the variability of symptoms among myotonia congenita patients, we searched for similar effects of [Mg(2+)]o and [Ca(2+)]o on myotonia in human muscle.
METHODS:
Bundles of muscle fibers were isolated from abdominal rectus in patients undergoing abdominal surgery. Myotonia was induced by ClC-1 inhibition using 9-anthracene carboxylic acid (9-AC) and was assessed from integrals of force induced by 5-Hz stimulation for 2 seconds.
RESULTS:
Myotonia disappeared gradually when [Mg(2+)]o or [Ca(2+)]o were elevated throughout their physiological ranges. These effects of [Mg(2+)]o and [Ca(2+)]o were additive and interchangeable.
CONCLUSIONS:
These findings suggest that variations in symptoms in myotonia congenita patients may arise from physiological variations in serum Mg(2+) and Ca(2+).
AuthorsMartin Skov, Frank Vincenzo De Paoli, Jesper Lausten, Ole Baekgaard Nielsen, Thomas Holm Pedersen
JournalMuscle & nerve (Muscle Nerve) Vol. 51 Issue 1 Pg. 65-71 (Jan 2015) ISSN: 1097-4598 [Electronic] United States
PMID24710922 (Publication Type: Journal Article)
Copyright© 2014 Wiley Periodicals, Inc.
Chemical References
  • Anthracenes
  • CLC-1 channel
  • Chloride Channels
  • 9-anthroic acid
  • Magnesium
  • Calcium
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Anthracenes (pharmacology)
  • Area Under Curve
  • Biophysics
  • Calcium (pharmacology)
  • Chloride Channels (antagonists & inhibitors, metabolism)
  • Dose-Response Relationship, Drug
  • Electric Stimulation
  • Female
  • Humans
  • In Vitro Techniques
  • Magnesium (pharmacology)
  • Male
  • Middle Aged
  • Muscle Contraction (drug effects)
  • Muscle Fibers, Skeletal (drug effects, pathology)
  • Myotonia (chemically induced)

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