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Role of oxidative stress in the pathogenesis of vitiligo with special emphasis on the antioxidant action of narrowband ultraviolet B phototherapy.

AbstractOBJECTIVES:
To evaluate the role of oxidative stress in the pathogenesis of vitiligo and the effect of narrowband (NB) ultraviolet (UV) B phototherapy on oxidative stress markers.
METHODS:
Patients with vitiligo and healthy control subjects were included in the study. Patients in the vitiligo group were treated with an NB-UVB regimen (3 × weekly for 6 months). Erythrocyte superoxide dismutase activity (SOD), erythrocyte malonyldialdehyde (MDA) and erythrocyte glutathione peroxidase activity (GSH-Px) levels were assessed in all participants at baseline, and after NB-UVB phototherapy in patients with vitiligo.
RESULTS:
A total of 24 patients with vitiligo and 27 control subjects were included in the study. Before treatment, erythrocyte MDA levels were significantly higher, and SOD and GSH-Px levels were significantly lower, in patients with vitiligo compared with controls. NB-UVB phototherapy was associated with a significant reduction in MDA levels and a significant increase in GSH-Px levels, compared with baseline, in patients with vitiligo.
CONCLUSION:
NB-UVB phototherapy may relieve oxidative stress in patients with vitiligo by reversing the oxidant-antioxidant imbalance that is considered to play a role in the pathogenesis of this disease.
AuthorsNeslihan Karsli, Cenk Akcali, Orhan Ozgoztasi, Necmettin Kirtak, Serhat Inaloz
JournalThe Journal of international medical research (J Int Med Res) Vol. 42 Issue 3 Pg. 799-805 (Jun 2014) ISSN: 1473-2300 [Electronic] England
PMID24709883 (Publication Type: Journal Article)
Copyright© The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
Chemical References
  • Malondialdehyde
  • Glutathione Peroxidase
  • Superoxide Dismutase
Topics
  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Erythrocytes (metabolism, radiation effects)
  • Female
  • Glutathione Peroxidase (blood)
  • Humans
  • Male
  • Malondialdehyde (blood)
  • Middle Aged
  • Oxidation-Reduction
  • Oxidative Stress (radiation effects)
  • Superoxide Dismutase (blood)
  • Treatment Outcome
  • Ultraviolet Rays
  • Ultraviolet Therapy
  • Vitiligo (blood, pathology, radiotherapy)

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