Abstract | OBJECTIVES: To evaluate the role of oxidative stress in the pathogenesis of vitiligo and the effect of narrowband (NB) ultraviolet (UV) B phototherapy on oxidative stress markers. METHODS: RESULTS: A total of 24 patients with vitiligo and 27 control subjects were included in the study. Before treatment, erythrocyte MDA levels were significantly higher, and SOD and GSH-Px levels were significantly lower, in patients with vitiligo compared with controls. NB-UVB phototherapy was associated with a significant reduction in MDA levels and a significant increase in GSH-Px levels, compared with baseline, in patients with vitiligo. CONCLUSION: NB-UVB phototherapy may relieve oxidative stress in patients with vitiligo by reversing the oxidant- antioxidant imbalance that is considered to play a role in the pathogenesis of this disease.
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Authors | Neslihan Karsli, Cenk Akcali, Orhan Ozgoztasi, Necmettin Kirtak, Serhat Inaloz |
Journal | The Journal of international medical research
(J Int Med Res)
Vol. 42
Issue 3
Pg. 799-805
(Jun 2014)
ISSN: 1473-2300 [Electronic] England |
PMID | 24709883
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav. |
Chemical References |
- Malondialdehyde
- Glutathione Peroxidase
- Superoxide Dismutase
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Topics |
- Adolescent
- Adult
- Aged
- Case-Control Studies
- Erythrocytes
(metabolism, radiation effects)
- Female
- Glutathione Peroxidase
(blood)
- Humans
- Male
- Malondialdehyde
(blood)
- Middle Aged
- Oxidation-Reduction
- Oxidative Stress
(radiation effects)
- Superoxide Dismutase
(blood)
- Treatment Outcome
- Ultraviolet Rays
- Ultraviolet Therapy
- Vitiligo
(blood, pathology, radiotherapy)
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