Abstract | BACKGROUND: METHODS: We studied the mRNA and protein levels of CCNG2 and CDK4 in VAT and SAT from 12 nonobese and 23 morbidly obese patients (11 with low [MO-L-IR] and 12 with high insulin resistance [MO-H-IR]). RESULTS: The nonobese patients had a significantly greater CCNG2 expression in VAT (P = .004) and SAT (P<.001) than the MO-L-IR and MO-H-IR patients. The MO-H-IR patients had a significantly lower CDK4 expression in VAT than the MO-L-IR (P = .026), but similar to the nonobese patients. CDK4 and CCNG2 expression correlated significantly in VAT (r = 0.511, P<.001) and SAT (r = .535, P = .001). In different multiple regression analysis models, CCNG2 and CDK4 expression in VAT was mainly predicted by glucose (P = .047 and P = .008, respectively), and CCNG2 expression in SAT was mainly predicted by body mass index (P = .041). No significant associations were found with CDK4 expression in SAT. Moreover, VAT CCNG2 expression was the main determinant of the improvement in the homeostasis model assessment of insulin resistance index at 3 months after bariatric surgery (B = -271.7, P = .026). CONCLUSION: Our data show for the first time that the human CCNG2 and CDK4 expression of VAT are inversely associated with glucose and insulin resistance.
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Authors | Lourdes Garrido-Sánchez, Maria del Mar Roca-Rodríguez, Sonia Fernández-Veledo, Joan Vendrell, Elena María Yubero-Serrano, Luis Ocaña-Wilhelmi, Eduardo García-Fuentes, Francisco Jose Tinahones |
Journal | Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
(Surg Obes Relat Dis)
2014 Jul-Aug
Vol. 10
Issue 4
Pg. 691-6
ISSN: 1878-7533 [Electronic] United States |
PMID | 24708911
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Cyclin G2
- RNA, Messenger
- CDK4 protein, human
- Cyclin-Dependent Kinase 4
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Topics |
- Adult
- Bariatric Surgery
- Body Mass Index
- Case-Control Studies
- Cyclin G2
(genetics, metabolism)
- Cyclin-Dependent Kinase 4
(genetics, metabolism)
- Female
- Humans
- Insulin Resistance
(physiology)
- Intra-Abdominal Fat
(metabolism)
- Male
- Middle Aged
- Obesity, Morbid
(metabolism, surgery)
- Prospective Studies
- RNA, Messenger
(metabolism)
- Subcutaneous Fat
(metabolism)
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