Abstract | OBJECTIVE: The Acute Respiratory Distress Syndrome Network protocol recommends limiting tidal volume and plateau pressure; it also recommends increasing respiratory rate to prevent hypercapnia. We tested a strategy that combines the low tidal volume with lower respiratory rates and minimally invasive CO2 removal. SUBJECTS: Ten lung-damaged pigs (instilled hydrochloride). INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: Physiological parameters, computed tomography scans, plasma and bronchoalveolar lavage concentrations of interleukin-1β, interleukin-6, interleukin-8, interleukin-10, interleukin-18, and tumor necrosis factor-α. During the lower respiratory rate condition, respiratory rate was reduced from 30.5 ± 3.8 to 14.2 ± 3.5 (p < 0.01) breaths/min and minute ventilation from 10.4 ± 1.6 to 4.9 ± 1.7 L/min (p < 0.01). The extracorporeal device removed 38.9% ± 6.1% (79.9 ± 18.4 mL/min) of CO2 production. During the lower respiratory rate condition, interleukin-6, interleukin-8, and tumor necrosis factor-α concentrations were significantly lower in plasma; interleukin-6 and tumor necrosis factor-α concentrations were lower in bronchoalveolar lavage, whereas the concentrations of the other cytokines remained unchanged. CONCLUSION: The strategy of lower respiratory rate plus minimally invasive extracorporeal CO2 removal was feasible and safe and, as compared with the Acute Respiratory Distress Syndrome Network protocol, reduced the concentrations of some, but not all, of the tested cytokines without affecting respiratory mechanics, gas exchange, and hemodynamics.
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Authors | Salvatore Grasso, Tania Stripoli, Palma Mazzone, Marco Pezzuto, Luca Lacitignola, Paola Centonze, Alessandro Guarracino, Cosimo Esposito, Peter Herrmann, Michael Quintel, Paolo Trerotoli, Francesco Bruno, Antonio Crovace, Francesco Staffieri |
Journal | Critical care medicine
(Crit Care Med)
Vol. 42
Issue 6
Pg. e451-60
(Jun 2014)
ISSN: 1530-0293 [Electronic] United States |
PMID | 24705570
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Animals
- Bronchoalveolar Lavage Fluid
- Cytokines
(analysis)
- Disease Models, Animal
- Extracorporeal Membrane Oxygenation
(instrumentation, methods)
- Feasibility Studies
- Female
- Hemodynamics
- Lung
(metabolism, physiopathology)
- Positive-Pressure Respiration
(adverse effects, methods, standards)
- Practice Guidelines as Topic
- Respiratory Distress Syndrome
(chemically induced, metabolism, therapy)
- Respiratory Mechanics
- Respiratory Rate
- Swine
- Tidal Volume
- Ventilator-Induced Lung Injury
(prevention & control)
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