Abstract | BACKGROUND: METHODS: One hundred patients with acute chikungunya with and without viral load and 250 chikungunya negative controls from western India were studied for the distribution of HLA class II alleles by PCR with sequence-specific primer (SSP) method. RESULTS: Frequency of DRB1*11 allele group (patients vs controls: p=0.002, Pc=0.036, OR=0.21) and haplotype DRB1*11/DQB1*03 (patients vs controls: p=0.007, OR=0.15) were significantly low, while haplotype DRB1*04/DQB1*03 (patients vs controls: p=0.042, OR=1.94) was significantly high in the patient population. HLA DQB1*04 allele was found only in the patient group with viral load (n=17), suggesting possible involvement of the same with chikungunya virus (CHIKV) replication. CONCLUSIONS: Association of HLA-DRB1*11 and the emergence of DRB1*11/DQB1*03 & DRB1*04/DQB1*03 as resistant and susceptible haplotypes towards CHIKV infection is being reported for the first time. Our results suggest that genetic susceptibility and/or resistance to chikungunya infection may be modulated by HLA class II alleles.
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Authors | Subrat Thanapati, Aparna Hande, Rumki Das, Yogesh Gurav, Anuradha S Tripathy |
Journal | Transactions of the Royal Society of Tropical Medicine and Hygiene
(Trans R Soc Trop Med Hyg)
Vol. 108
Issue 5
Pg. 277-82
(May 2014)
ISSN: 1878-3503 [Electronic] England |
PMID | 24699361
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HLA Antigens
- HLA-DRB1 Chains
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Animals
- Chikungunya Fever
(epidemiology, genetics, immunology)
- Child
- Disease Outbreaks
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- HLA Antigens
- HLA-DRB1 Chains
(immunology)
- Humans
- Immunity, Innate
(genetics, immunology)
- India
(epidemiology)
- Male
- Middle Aged
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