Transcriptional regulation alone does not explain the constitutive expression of the interleukin 2 receptor (Tac/L-chain) in HTLV-1 infected cells.

Abstract

We have identified a suppressive element in the upstream region of the interleukin 2 (IL-2) receptor L chain (Tac) promoter. The inhibitory activity of this element was retained in human T cell leukemia virus type-1 (HTLV-1)-infected T cell lines which express constitutively a large number of IL-2 receptors on the cell surface. The promoter activities of the IL-2 receptor gene did not always correlate with the strong expression of the receptor and its mRNA in the HTLV-1-infected T cell lines we analysed. The results indicate that the constitutive up-regulation of the IL-2 receptor in HTLV-1-infected T cells may be ascribed to not only the transcriptional but also post-transcriptional regulation.

• Authors: H Kanamori, N Suzuki, N Ishida, T Honjo
• Journal: Immunology letters (Immunol Lett) Vol. 20 Issue 4 Pg. 293-8 (Mar 1989) ISSN: 0165-2478 [Print] Netherlands
• PMID: 2469652 (Publication Type: Journal Article)

Chemical References

• Receptors, Interleukin-2
• RNA

Topics

• Gene Expression Regulation
• HTLV-I Infections (genetics, metabolism)
• Humans
• RNA (analysis, isolation & purification)
• Receptors, Interleukin-2 (metabolism)
• T-Lymphocytes (immunology)
• Transcription, Genetic
• Transfection