Efficacy of thyrotropin-releasing hormone in the treatment of cerebellar ataxia.

Abstract

We report a 9-year-old girl with cerebellar ataxia in whom the administration of thyrotropin-releasing hormone was effective in the treatment of a prolonged neurologic deficit. Ataxia persisted 18 months after its acute onset of unknown origin. Concentrations of homovanillic acid and 5-hydroxy-indoleacetic acid in the cerebrospinal fluid were measured repeatedly. Changes in the 5-hydroxy-indoleacetic/homovanillic acid ratio were observed, suggesting that thyrotropin-releasing hormone improved symptoms by influencing serotonin metabolism in the central nervous system.

• Authors: Y Takeuchi, K Fujiwara, K Ishimura, Y Shimada, M Ochi, H Yoshioka, T Sawada
• Journal: Pediatric neurology (Pediatr Neurol) 1989 Mar-Apr Vol. 5 Issue 2 Pg. 107-10 ISSN: 0887-8994 [Print] United States
• PMID: 2469426 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hydroxyindoleacetic Acid
• Thyrotropin-Releasing Hormone
• Homovanillic Acid

Topics

• Cerebellar Ataxia (cerebrospinal fluid, drug therapy)
• Child
• Female
• Homovanillic Acid (cerebrospinal fluid)
• Humans
• Hydroxyindoleacetic Acid (cerebrospinal fluid)
• Thyrotropin-Releasing Hormone (therapeutic use)