Abstract | AIM: METHODS: We analyzed 114 tumor tissues from ovarian tumors, including 44 adult-type and two juvenile-type GCT of the ovary and 68 ovarian tumors by DNA sequencing. Immunohistochemistry was also performed in the adult and juvenile GCT tissues by immunostaining inhibin-α, BMP2 and FST. RESULTS: We found the FOXL2 p.C134W mutation in 27 out of 44 (61.4%) adult-type GCT of the ovary, but none in other ovarian tumors. Histologically, all of the adult-type GCT sections were positive for inhibin-α, and the expression of BMP2 and FST was detected in 14 of 44 (31.8%) and zero of 47 (0%), respectively. No significant differences regarding the diagnosed age, preoperative serum carbohydrate antigen 125 levels, or BMP2 immunopositivity between the FOXL2 p.C134W mutation-positive and mutation-negative were found in the adult-type GCT patients. CONCLUSION: Our findings suggest that FOXL2 p.C134W mutation-positive adult-type GCT of the ovary may not be common in the Japanese as compared to the previous data.
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Authors | Kumiko Oseto, Nobuhiro Suzumori, Ryutaro Nishikawa, Hiroshi Nishikawa, Atsushi Arakawa, Yasuhiko Ozaki, Hidekazu Asai, Michiyasu Kawai, Kimio Mizuno, Satoru Takahashi, Tomoyuki Shirai, Chisato Yamada-Namikawa, Makoto Nakanishi, Hiroaki Kajiyama, Fumitaka Kikkawa, Mayumi Sugiura-Ogasawara |
Journal | The journal of obstetrics and gynaecology research
(J Obstet Gynaecol Res)
Vol. 40
Issue 5
Pg. 1197-204
(May 2014)
ISSN: 1447-0756 [Electronic] Australia |
PMID | 24689977
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology. |
Chemical References |
- BMP2 protein, human
- Bone Morphogenetic Protein 2
- FOXL2 protein, human
- Forkhead Box Protein L2
- Forkhead Transcription Factors
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Topics |
- Adult
- Bone Morphogenetic Protein 2
(analysis)
- Female
- Forkhead Box Protein L2
- Forkhead Transcription Factors
(genetics)
- Granulosa Cell Tumor
(chemistry, genetics)
- Humans
- Immunohistochemistry
- Mutation
- Ovarian Neoplasms
(chemistry, genetics)
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