Transdermal clonidine in the treatment of severe hyperemesis. A pilot randomised control trial: CLONEMESI.

Abstract

OBJECTIVE:

To study the efficacy of transdermal clonidine in the treatment of severe refractory hyperemesis gravidarum (HG), the most severe illness of pregnancy.

DESIGN:

The study had a randomised, double -blind, placebo-controlled, cross-over design (RCT).

SETTING:

Single tertiary referral hospital after admission of patients.

SAMPLE:

Twelve women of gestational age 6-12 weeks and a major grade of HG clinical severity who were unresponsive to standard antiemetic treatment.

METHODS:

The patients were randomly treated with and without the active drug (5 mg patch) for two consecutive periods of 5 days. The patients were allocated to a random list to receive first placebo and then active drug or the other way round. Other antiemetic drugs were administered on a scheduled or as-needed basis. All patients received intravenous hydration and thiamine supplementation.

MAIN OUTCOME MEASURES:

Pregnancy Unique Quantification of Emesis (PUQE) and visual analog scale (VAS) clinical scores, positive morning urine ketonuria, number of doses of standard antiemetic drugs required, and number of days off intravenous therapy were compared in the two periods.

RESULTS:

Transdermal clonidine led to a significantly greater improvement compared with placebo of the primary (PUQE score P = 0.026 CI 0.43-3.24; VAS score P = 0.010 CI 2.17-12.83) and secondary outcome measures. A reduction of blood pressure was reported for systolic 6 mmHg P = 0.01 and diastolic 3 mmHg P = 0.055.

CONCLUSIONS:

This preliminary RCT demonstrates the efficacy of transdermal clonidine in the treatment of severe HG, leading to a significant reduction of symptoms and reducing the need for other supportive measures and medications.

• Authors: A Maina, M Arrotta, L Cicogna, V Donvito, M Mischinelli, T Todros, S Rivolo
• Journal: BJOG : an international journal of obstetrics and gynaecology (BJOG) Vol. 121 Issue 12 Pg. 1556-62 (Nov 2014) ISSN: 1471-0528 [Electronic] England
• PMID: 24684734 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 Royal College of Obstetricians and Gynaecologists.

Chemical References

• Antiemetics
• Clonidine

Topics

• Administration, Cutaneous
• Adult
• Antiemetics (administration & dosage, therapeutic use)
• Clonidine (administration & dosage, therapeutic use)
• Cross-Over Studies
• Double-Blind Method
• Drug Administration Schedule
• Female
• Humans
• Hyperemesis Gravidarum (drug therapy)
• Pilot Projects
• Pregnancy
• Severity of Illness Index
• Treatment Outcome