Abstract | OBJECTIVES: METHODS: Blood samples were obtained between October 2012 and June 2013 from 587 healthy subjects aged 2-17 years. Serum IgG antibodies against diphtheria and tetanus were determined using ELISA. Interrupted time series analyses examined the changes in antitoxin levels over time and analyzed the alterations in diphtheria and tetanus antitoxin levels after the vaccine switch. RESULTS: CONCLUSIONS: Although the observed protection rates for diphtheria and tetanus were sufficient to prevent an outbreak at present, the means levels of diphtheria and tetanus antitoxins decreased with increasing age; therefore, booster vaccinations at 7 and 12 years of age would be strengthened in Gaobeidian city, China.
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Authors | Yuyan Wu, Yuan Gao, Bingqing Zhu, Haijian Zhou, Zhenhua Shi, Junsheng Wang, Haipo Wang, Zhujun Shao |
Journal | Vaccine
(Vaccine)
Vol. 32
Issue 22
Pg. 2570-3
(May 07 2014)
ISSN: 1873-2518 [Electronic] Netherlands |
PMID | 24681275
(Publication Type: Journal Article)
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Copyright | Copyright © 2014. Published by Elsevier Ltd. |
Chemical References |
- Antibodies, Bacterial
- Diphtheria Antitoxin
- Diphtheria-Tetanus-Pertussis Vaccine
- Diphtheria-Tetanus-acellular Pertussis Vaccines
- Immunoglobulin G
- Tetanus Antitoxin
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Topics |
- Adolescent
- Antibodies, Bacterial
(blood)
- Asian People
- Child
- Child, Preschool
- China
- Cross-Sectional Studies
- Diphtheria Antitoxin
(blood)
- Diphtheria-Tetanus-Pertussis Vaccine
(administration & dosage)
- Diphtheria-Tetanus-acellular Pertussis Vaccines
(administration & dosage)
- Female
- Humans
- Immunoglobulin G
(blood)
- Male
- Tetanus Antitoxin
(blood)
- Time Factors
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