Abstract | PURPOSE: MATERIALS AND METHODS: Age matched rats were divided into groups, including simulated surgery without testicular torsion, 720-degree testicular torsion for 4 hours, testicular torsion with resveratrol treatment and testicular torsion with arginine treatment. To study reproductive function at age 12 weeks each rat mated with 3 females. The males were sacrificed at age 14 weeks. Spermatozoids were collected from the epididymal tail and evaluated for concentration, motility and viability. Testicular samples were collected for morphological analysis. RESULTS: CONCLUSIONS: Testicular morphology was altered less in rats when torsion occurred earlier in life, that is during puberty. Treatment with antioxidants improved contralateral spermatozoid production and some fertility parameters. Each antioxidant also prevented testicular morphology alterations after testicular torsion. Prepubertal rats benefited most from antioxidant treatment.
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Authors | Carina T Ribeiro, Raquel Milhomem, Diogo B De Souza, Waldemar S Costa, Francisco J B Sampaio, Marco A Pereira-Sampaio |
Journal | The Journal of urology
(J Urol)
Vol. 191
Issue 5 Suppl
Pg. 1578-84
(May 2014)
ISSN: 1527-3792 [Electronic] United States |
PMID | 24679870
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Antioxidants
- Stilbenes
- Arginine
- Resveratrol
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Topics |
- Animals
- Antioxidants
(therapeutic use)
- Arginine
(pharmacology, therapeutic use)
- Male
- Rats
- Resveratrol
- Spermatic Cord Torsion
(pathology, physiopathology, surgery)
- Stilbenes
(therapeutic use)
- Testis
(drug effects, pathology, physiopathology)
- Treatment Outcome
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