[Differences in electrophoretic mobility and cytochemistry of leukemic T-cells with identical immunologic phenotype (CD1 positive)].

Abstract

Leukaemic cells of acute T-lymphoblastic leukaemia and T-lymphoblastic lymphoma with secondary leukaemic course of disease which showed the same immunological phenotype (cortical thymocytes, thymocyte stage II), could be further differentiated according to their cytochemical pattern and electrophoretic mobility (EPM). Leukaemic cells of T-ALL usually reveal a high EPM, whereas EPM of leukaemic cells of T-lymphoblastic lymphoma was significantly lowered. In cytochemical respect acid phosphatase was positive in both cases of leukaemia. An activity of acid esterase, however, could only be demonstrated in leukaemic cells of T-lymphoblastic lymphoma. The findings are interpreted as manifestation of a different stage of maturity of both T-cell clones with the same immunological phenotype.

• Authors: J Rychly, V Lakner, P Nowotny
• Journal: Folia haematologica (Leipzig, Germany : 1928) (Folia Haematol Int Mag Klin Morphol Blutforsch) Vol. 115 Issue 6 Pg. 837-45 ( 1988) ISSN: 0323-4347 [Print] Germany
• Vernacular Title: Unterschiede in der elektrophoretischen Mobilität und Zytochemie leukämischer T-Zellen mit gleichem immunologischen Phänotyp (CD 1 positiv).
• PMID: 2467855 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antigens, Differentiation, T-Lymphocyte

Topics

• Adolescent
• Adult
• Antigens, Differentiation, T-Lymphocyte
• Cell Movement
• Electrophoresis
• Histocytochemistry
• Humans
• Leukemia, Lymphocytic, Chronic, B-Cell (metabolism, pathology)
• Leukemia-Lymphoma, Adult T-Cell (metabolism, pathology)
• Male
• Phenotype
• T-Lymphocytes (analysis, classification, pathology)