[Differences in electrophoretic mobility and cytochemistry of leukemic T-cells with identical immunologic phenotype (CD1 positive)].

Leukaemic cells of acute T-lymphoblastic leukaemia and T-lymphoblastic lymphoma with secondary leukaemic course of disease which showed the same immunological phenotype (cortical thymocytes, thymocyte stage II), could be further differentiated according to their cytochemical pattern and electrophoretic mobility (EPM). Leukaemic cells of T-ALL usually reveal a high EPM, whereas EPM of leukaemic cells of T-lymphoblastic lymphoma was significantly lowered. In cytochemical respect acid phosphatase was positive in both cases of leukaemia. An activity of acid esterase, however, could only be demonstrated in leukaemic cells of T-lymphoblastic lymphoma. The findings are interpreted as manifestation of a different stage of maturity of both T-cell clones with the same immunological phenotype.
AuthorsJ Rychly, V Lakner, P Nowotny
JournalFolia haematologica (Leipzig, Germany : 1928) (Folia Haematol Int Mag Klin Morphol Blutforsch) Vol. 115 Issue 6 Pg. 837-45 ( 1988) ISSN: 0323-4347 [Print] GERMANY, EAST
Vernacular TitleUnterschiede in der elektrophoretischen Mobilität und Zytochemie leukämischer T-Zellen mit gleichem immunologischen Phänotyp (CD 1 positiv).
PMID2467855 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Antigens, Differentiation, T-Lymphocyte
  • Adolescent
  • Adult
  • Antigens, Differentiation, T-Lymphocyte
  • Cell Movement
  • Electrophoresis
  • Histocytochemistry
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell (metabolism, pathology)
  • Leukemia-Lymphoma, Adult T-Cell (metabolism, pathology)
  • Male
  • Phenotype
  • T-Lymphocytes (analysis, classification, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: