[Autosomal dominant polycystic kidney disease in hemodialysis patients in Southern Brazil].

Abstract

INTRODUCTION:

Autosomal dominant polycystic kidney disease is the most common hereditary renal disease in humans.

OBJECTIVE:

To examine the prevalence, clinical and laboratory characteristics of patients with polycystic kidneys and relate disease manifestations by gender.

METHODS:

This was an observational and retrospective study. All the medical records of patients with polycystic kidneys who initiated hemodialysis between 1995 and 2012, in four centers that treat patients of the coverage area of the 15th regional health Paraná (Brazil), were analyzed.

RESULTS:

The study included 48 patients with polycystic kidneys, the primary cause of stage 5 CKD. Disease prevalence was one in 10,912 people. The average age of dialysis initiation was 50.7 years and the follow-up time on dialysis until transplantation (36.5 months) was lower among men. Hypertension was the most frequent diagnosis in 73% of patients, predominantly in women (51.4%). The liver cyst was the most frequent extrarenal manifestations in men (60.0%). The death occurred in 10.4% of patients using hemodialysis, and 60% of men. The class of antihypertensive drug used was that acts on the renin-angiotensin system with higher frequency of use among women (53.3%). The post-dialysis urea was significantly higher in men.

CONCLUSION:

The prevalence of the disease is low among hemodialysis patients in southern Brazil. The differences observed between genders, with the exception of the post-dialysis urea, were not significant. The findings are different from those reported in North America and Europe.

• Authors: Everton Fernando Alves, Luiza Tamie Tsuneto, Sandra Marisa Pelloso, Paulo Roberto Aranha Torres, Guido Luis Gomes Otto, Adaelson Alves Silva, José Miguel Viscarra Obregon, Letícia Nicoletti Silva, Maria Dalva de Barros Carvalho
• Journal: Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia (J Bras Nefrol) 2014 Jan-Mar Vol. 36 Issue 1 Pg. 18-25 ISSN: 2175-8239 [Electronic] Brazil
• Vernacular Title: Doenca renal policistica autossomica dominante em pacientes em hemodialise no sul do Brasil.
• PMID: 24676610 (Publication Type: English Abstract, Journal Article, Observational Study)

Topics

• Brazil (epidemiology)
• Female
• Humans
• Male
• Middle Aged
• Polycystic Kidney, Autosomal Dominant (diagnosis, epidemiology, therapy)
• Prevalence
• Renal Dialysis
• Retrospective Studies