Abstract | BACKGROUND AND AIM: METHODS: Serum Tβ4 levels were measured by enzyme-linked immunosorbent assay (ELISA), and the CTP and MELD scores were calculated for each patient. RESULTS: Serum Tβ4 levels of AoCLF patients [0.4120 (0.2447-0.7492)μg/mL] were lower than healthy controls [9.2710 (5.1660-13.2485)μg/mL] (P<0.001). AoCLF patients were divided into survival and death group. Compared to survivors, lower Tβ4 concentrations, higher CTP and MELD scores (P<0.001, respectively) were observed in AoCLF patients who died. There were negative correlations between Tβ4 levels and CTP scores (P<0.001), MELD scores (P<0.001). A CTP score of 11.5, a MELD score of 21.63 and a Tβ4 concentration of 0.3840μg/mL were identified as the cut-off values for the stratification of AoCLF patients. MELD≥21.63 combined with Tβ4<0.3840μg/mL can more exactly discriminate between the patients who would survive and die. CONCLUSIONS: Serum Tβ4 concentration has appreciable value to evaluate the short-term prognosis of AoCLF patients, although Tβ4 is not superior to MELD. The combination of Tβ4 and MELD scores are more effective in assessing the prognosis of AoCLF patients.
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Authors | Ying Liu, Tao Han, Zheng-yan Zhu, Ying Li |
Journal | Clinics and research in hepatology and gastroenterology
(Clin Res Hepatol Gastroenterol)
Vol. 38
Issue 3
Pg. 310-7
(Jun 2014)
ISSN: 2210-741X [Electronic] France |
PMID | 24674841
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Masson SAS. All rights reserved. |
Chemical References |
- Biomarkers
- thymosin beta(4)
- Thymosin
|
Topics |
- Acute-On-Chronic Liver Failure
(blood, mortality)
- Biomarkers
(blood)
- Case-Control Studies
- Female
- Humans
- Male
- Middle Aged
- Predictive Value of Tests
- Prognosis
- Sensitivity and Specificity
- Severity of Illness Index
- Thymosin
(blood)
|