[A clinical analysis of thyrotropin-secreting pituitary adenomas in 20 patients].

Abstract

OBJECTIVE:

To explore the clinical characteristics of thyrotropin-secreting pituitary adenomas.

METHODS:

A total of 20 patients with thyrotropin-secreting pituitary adenomas hospitalized in Shanghai Huashan Hospital from 2006 to 2013 were enrolled in the study. The clinical features, hormone levels, imaging findings, treatment and follow-up data were reviewed and analyzed.

RESULTS:

Most of the patients were young and middle-aged with (40.0 ± 14.5) years old. The disease duration varied from 1 month to 15 years. Among them, 13 cases (65%) presented with thyrotoxicosis and/or thyroid goiters and 9 (45%) presented with symptoms of intracranial compression. All patients had unsuppressed levels of thyroid stimulating hormone (TSH) with elevated levels of thyroid hormones. Pituitary lesions were found in all patients by neuroimaging. Pituitary adenomectomy, and/or somatostatin analogs and/or radiotherapy were applied in all patients after definitive diagnosis. Restored euthyroidism and shrinks pituitary adenomas with no progression were observed in 18 patients. Relapse was found in 1 patient and another patient was lost to follow up.

CONCLUSIONS:

Thyrotropin-secreting pituitary adenomas mainly present with thyrotoxicosis and/or pituitary tumor. Comprehensive therapy, including adenomectomy, somatostatin analogues and radiotherapy, is often needed for the management.

• Authors: Weiwei Zhao, Yehong Yang, Hongying Ye, Zhaoyun Zhang, Bin Lu, Xi Wu, Renming Hu, Linuo Zhou, Shiqi Li, Yiming Li
• Journal: Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 53 Issue 1 Pg. 19-22 (Jan 2014) ISSN: 0578-1426 [Print] China
• PMID: 24674722 (Publication Type: Journal Article)

Chemical References

• Thyrotropin

Topics

• Adolescent
• Adult
• Female
• Humans
• Male
• Middle Aged
• Pituitary Neoplasms (diagnosis, therapy)
• Thyrotropin (metabolism)
• Young Adult