Pompholyx is a common eruption of small vesicles on the palms, soles, and/or lateral aspects of the fingers. It has a multifactorial etiology, including genetic determinants,
allergy to metals, and id reaction; rarely it is a
drug-related side effect. We report a paediatric case of
pompholyx of the hands related to the
intravenous immunoglobulin (
IVIG)
therapy for Clinically Isolated Syndrome (CIS). A 10-year-old boy, received an
IVIG therapy (Venital, Kedrion Spa, Italy) at a dose of 400 mg/kg daily for five days. The fifth day of
IVIG infusion, a symmetrical vesicular eruption appeared on the palms of the hands and on lateral aspects of the fingers. The lesions improved with application of topical
steroids in few days. The mechanism of induction of
pompholyx by
IVIG therapy is unknown. A review of the Literature suggests the hypothesis that dyshidrotic eczematous reactions may be related not only to the type of
IVIG, to the dose and the rates of infusion, but also to an allergic response to
excipients and preservatives contained in the
drug, probably elicited by an underlying neurological disease in some cases.