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Facing the challenges of new melanoma-targeted therapies: Treatment of severe fevers associated with dabrafenib/trametinib combination therapy.

Abstract
With the emergence of new oral therapies for metastatic melanoma to the market, as well as ongoing pre-marketing trials and special access schemes, it is important to keep up to date with the side effect profiles of these medications. A common side effect associated with the BRAF inhibitor dabrafenib is severe fever symptoms such as pyrexia and rigors/chills; however, treatment options are limited. We report a patient who was debilitated by severe pyrexia and rigors caused by dabrafenib used in combination with trametinib to treat metastatic melanoma, who was treated with low-dose steroids. To our knowledge, the use of prednisolone for the treatment and prevention of further dabrafenib-associated pyrexia is not published; however, it is a low risk and low cost option that was very effective in this case.
AuthorsJulian N Lindsay, Michael Barras
JournalJournal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (J Oncol Pharm Pract) Vol. 21 Issue 4 Pg. 293-5 (Aug 2015) ISSN: 1477-092X [Electronic] England
PMID24664475 (Publication Type: Case Reports, Journal Article)
Copyright© The Author(s) 2014.
Chemical References
  • Cephalosporins
  • Imidazoles
  • Oximes
  • Pyridones
  • Pyrimidinones
  • trametinib
  • Cefepime
  • dabrafenib
Topics
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects)
  • Cefepime
  • Cephalosporins (therapeutic use)
  • Drug Delivery Systems (adverse effects)
  • Female
  • Fever (chemically induced, diagnosis, drug therapy)
  • Humans
  • Imidazoles (administration & dosage, adverse effects)
  • Melanoma (diagnosis, drug therapy)
  • Oximes (administration & dosage, adverse effects)
  • Pyridones (administration & dosage, adverse effects)
  • Pyrimidinones (administration & dosage, adverse effects)
  • Severity of Illness Index

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