Molecule 16673-34-0: a new tool in our arsenal against inflammation.

Abstract

The NLRP3 inflammasome has been shown to modulate IL-1B and IL-18 production, both key molecular regulators of inflammation. This editorial discusses a new molecule 16673-34-0 that inhibits the NLRP3 inflammasome and decreases caspase 1 production following ischemia reperfusion or acute peritonitis in mice.

• Authors: Michael J Lipinski, Juan C Frias
• Journal: Journal of cardiovascular pharmacology (J Cardiovasc Pharmacol) Vol. 63 Issue 4 Pg. 314-5 (Apr 2014) ISSN: 1533-4023 [Electronic] United States
• PMID: 24662491 (Publication Type: Journal Article)

Chemical References

• 5-chloro-2-methoxy-N-(2-(4-sulfamoylphenyl)ethyl)benzamide
• Anti-Inflammatory Agents, Non-Steroidal
• Benzamides
• Blood Glucose
• Carrier Proteins
• Inflammasomes
• NLR Family, Pyrin Domain-Containing 3 Protein
• Nlrp3 protein, mouse
• Sulfonamides

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Benzamides (chemical synthesis, therapeutic use)
• Blood Glucose (metabolism)
• Carrier Proteins (antagonists & inhibitors)
• Cell Line
• Inflammasomes (antagonists & inhibitors)
• Macrophages (drug effects)
• Male
• Mice
• Myocardial Reperfusion Injury (drug therapy)
• NLR Family, Pyrin Domain-Containing 3 Protein
• Peritonitis (chemically induced, prevention & control)
• Sulfonamides (chemical synthesis, therapeutic use)