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[A case of AFP-producing gastric cancer accompanied with testicular tumor].

Abstract
A case of an AFP-producing gastric cancer accompanied with non-epithelial tumor is reported. A 63-year-old man, complaining of an epigastric hunger pain, was admitted to our hospital. Testing revealed that he had an extremely high level serum AFP (12,400 ng/ml) with no abnormality of liver function. A barium ingestion and a subsequent endoscopic examination determined the existence of a Borrmann III type advanced gastric cancer on the lesser curvature, extending from middle corpus to the antrum. Diagnostic imaging did not reveal any metastatic lesion in liver. After a total gastrectomy, the patient's serum AFP level rapidly decreased, followed by a recurrence he developed of a carcinomatous pleuritis and death. On autopsy, an enlargement of the right testis was noticed for the first time. Histologically, it was found to be a malignant, non-epithelial tumor, which proved negative for anti-AFP staining by the ABC method and positive for anti *L-26. On the other hand, the gastric cancer was a poorly differentiated adenocarcinoma with a hepatoid differentiation which was positive for anti-AFP staining and negative for anti-L-26 so it thus was diagnosed as an AFP-producing gastric cancer.
AuthorsM Watanabe, Y Hamada, T Matsushima, T Miyazaki, H Katoh, A Kawamura, M Fujita, K Sano
JournalGan no rinsho. Japan journal of cancer clinics (Gan No Rinsho) Vol. 34 Issue 15 Pg. 2131-7 (Dec 1988) ISSN: 0021-4949 [Print] Japan
PMID2466135 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • alpha-Fetoproteins
Topics
  • Adenocarcinoma (metabolism, pathology)
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Neoplasms, Multiple Primary
  • Stomach Neoplasms (metabolism, pathology)
  • Testicular Neoplasms (pathology)
  • alpha-Fetoproteins (biosynthesis)

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