8-hydroxycudraxanthone G suppresses IL-8 production in SP-C1 tongue cancer cells.

Abstract

Production of IL-8 primarily promotes angiogenic responses in cancer cells, which lead to favorable disease progression. Suppressing this production may, therefore, be a significant therapeutic intervention in targeting tumor angiogenesis. This study aimed to evaluate the reduction effects of xanthones in cancer cell lines. Nine known prenylated xanthones (1-9), isolated from the pericarp of Garcinia mangostana Linn (GML), were tested for their ability to suppress IL-8 (interleukin-8) of the SP-C1 (Supri's Clone 1) tongue cancer cell line. Of these compounds, 8-hydroxycudraxanthone-G (4) suppressed IL-8 within 48 hours. This is the first report of 8-hydroxycudraxanthone G suppressing the production of IL-8 (45% at 15.7 microg/mL in 48 hours). These results suggest that the prolonged suppression of IL-8 production by cancer cell lines is concerned in the anti-cancer activity of 8-hydroxycudraxanthone.

• Authors: Arlette S Setiawan, Roosje R Oewen, Supriatno, Willyanti Soewondo, Sidik, Unang Supratman
• Journal: Natural product communications (Nat Prod Commun) Vol. 9 Issue 1 Pg. 75-8 (Jan 2014) ISSN: 1934-578X [Print] United States
• PMID: 24660467 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 8-hydroxycudraxanthone G
• Antineoplastic Agents, Phytogenic
• Interleukin-8
• Xanthones

Topics

• Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology, therapeutic use)
• Carcinoma, Squamous Cell (drug therapy)
• Cell Line, Tumor
• Drug Screening Assays, Antitumor
• Garcinia mangostana (chemistry)
• Humans
• Interleukin-8 (antagonists & inhibitors)
• Plants, Medicinal (chemistry)
• Tongue Neoplasms (drug therapy)
• Xanthones (isolation & purification, pharmacology, therapeutic use)