Kindlin-3 in the immune system.

Abstract

Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. In contrast to kindlin-1 and kindlin-2 proteins, kindlin-3 is expressed mainly in the hematopoietic system. Mutations in kindlin-3 result in the rare genetic disorder, leukocyte adhesion deficiency type III (LAD-III), which is characterized by bleeding and recurrent infections due to deficient beta1, beta2 and beta3 integrin activation in platelets and leukocytes. Here, we review the role of kindlin-3 in integrin activation and in different immune cell functions.

• Authors: Susanna C Fagerholm, Hwee San Lek, Vicky L Morrison
• Journal: American journal of clinical and experimental immunology (Am J Clin Exp Immunol) Vol. 3 Issue 1 Pg. 37-42 ( 2014) ISSN: 2164-7712 [Print] United States
• PMID: 24660120 (Publication Type: Journal Article, Review)