Abstract | PURPOSE: METHODS: HAI-1 protein was evaluated by immunohistochemistry (IHC) and HAI-1 mRNA was evaluated by reverse transcription-polymerase chain reaction (RT-PCR) in 48 patients with Pca and 20 patients with benign prostate hyperplasia (BPH). The association between HAI-1 and clinicopathological features and survival were analyzed. RESULTS: A high level of HAI-1 protein and mRNA expression was detected in BPH compared to Pca specimens. The HAI-1 expression inversely correlated with Gleason score and pathological stage (p<0.05). It was significantly stronger in N0M0 tumors than in N+ or M+ tumors (p<0.05). Furthermore, low HAI-1 expression was a significant predictor for poor prognosis when compared with high HAI-1 expression (disease-free survival/DFS rate, p=0.0487; overall survival/ OS rate; p=0.0492). CONCLUSION: The results of the present study identified HAI-1 as a favorable prognostic marker for Pca and may indicate that HAI-1 could be a therapeutic target for the treatment of this malignancy.
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Authors | Chuanyi Hu, Ning Jiang, Guozeng Wang, Jingcun Zheng, Wei Yang, Jiawei Yang |
Journal | Journal of B.U.ON. : official journal of the Balkan Union of Oncology
(J BUON)
2014 Jan-Mar
Vol. 19
Issue 1
Pg. 215-20
ISSN: 1107-0625 [Print] Cyprus |
PMID | 24659667
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Proteinase Inhibitory Proteins, Secretory
- SPINT1 protein, human
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Topics |
- Aged
- Biomarkers, Tumor
(biosynthesis, genetics)
- Disease-Free Survival
- Gene Expression Regulation, Neoplastic
- Humans
- Male
- Middle Aged
- Neoplasm Grading
- Prostatic Neoplasms
(genetics, pathology)
- Proteinase Inhibitory Proteins, Secretory
(biosynthesis, genetics)
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