Abstract |
IL-15 is involved in regulating host defense and inflammation. Monocytes produce the biologically active cell surface IL-15 in response to IFN-γ. Although aging can alter the immune system, little is known about whether and how aging affects IFN-γ-mediated IL-15 production in human monocytes. We showed that monocytes of healthy older adults (age ≥ 65) had increased cell surface IL-15 expression in response to IFN-γ compared to those of healthy young adults (age ≤ 40). This finding stems in part from increased IFN-γ receptor (R)1/2 expression on monocytes in older adults, leading to enhanced STAT1 activation and interferon regulatory factor 1 synthesis with increased IL15 gene expression. Our study suggests that with aging the IFN-γ-mediated IL-15 production pathway in human monocytes is uncompromised, but rather augmented, and could be considered as a therapeutic target point to modulate host defense and inflammation in older adults.
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Authors | Naeun Lee, Min Sun Shin, Ki Soo Kang, Seung-Ah Yoo, Subhasis Mohanty, Ruth R Montgomery, Albert C Shaw, Insoo Kang |
Journal | Clinical immunology (Orlando, Fla.)
(Clin Immunol)
2014 May-Jun
Vol. 152
Issue 1-2
Pg. 101-10
ISSN: 1521-7035 [Electronic] United States |
PMID | 24657713
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- IL15RA protein, human
- IRF1 protein, human
- Interferon Regulatory Factor-1
- Interleukin-15
- Receptors, Interferon
- Receptors, Interleukin-15
- STAT1 Transcription Factor
- STAT1 protein, human
- interferon gamma receptor
- Interferon-gamma
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Topics |
- Adult
- Age Factors
- Aging
(immunology)
- Humans
- Inflammation
(immunology)
- Interferon Regulatory Factor-1
(biosynthesis)
- Interferon-gamma
(metabolism)
- Interleukin-15
(biosynthesis, immunology, metabolism)
- Middle Aged
- Monocytes
(immunology, metabolism)
- Receptors, Interferon
(biosynthesis, immunology, metabolism)
- Receptors, Interleukin-15
(immunology, metabolism)
- STAT1 Transcription Factor
(immunology)
- Signal Transduction
(immunology)
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