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Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling.

Abstract
IL-15 is involved in regulating host defense and inflammation. Monocytes produce the biologically active cell surface IL-15 in response to IFN-γ. Although aging can alter the immune system, little is known about whether and how aging affects IFN-γ-mediated IL-15 production in human monocytes. We showed that monocytes of healthy older adults (age ≥ 65) had increased cell surface IL-15 expression in response to IFN-γ compared to those of healthy young adults (age ≤ 40). This finding stems in part from increased IFN-γ receptor (R)1/2 expression on monocytes in older adults, leading to enhanced STAT1 activation and interferon regulatory factor 1 synthesis with increased IL15 gene expression. Our study suggests that with aging the IFN-γ-mediated IL-15 production pathway in human monocytes is uncompromised, but rather augmented, and could be considered as a therapeutic target point to modulate host defense and inflammation in older adults.
AuthorsNaeun Lee, Min Sun Shin, Ki Soo Kang, Seung-Ah Yoo, Subhasis Mohanty, Ruth R Montgomery, Albert C Shaw, Insoo Kang
JournalClinical immunology (Orlando, Fla.) (Clin Immunol) 2014 May-Jun Vol. 152 Issue 1-2 Pg. 101-10 ISSN: 1521-7035 [Electronic] United States
PMID24657713 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • IL15RA protein, human
  • IRF1 protein, human
  • Interferon Regulatory Factor-1
  • Interleukin-15
  • Receptors, Interferon
  • Receptors, Interleukin-15
  • STAT1 Transcription Factor
  • STAT1 protein, human
  • interferon gamma receptor
  • Interferon-gamma
Topics
  • Adult
  • Age Factors
  • Aging (immunology)
  • Humans
  • Inflammation (immunology)
  • Interferon Regulatory Factor-1 (biosynthesis)
  • Interferon-gamma (metabolism)
  • Interleukin-15 (biosynthesis, immunology, metabolism)
  • Middle Aged
  • Monocytes (immunology, metabolism)
  • Receptors, Interferon (biosynthesis, immunology, metabolism)
  • Receptors, Interleukin-15 (immunology, metabolism)
  • STAT1 Transcription Factor (immunology)
  • Signal Transduction (immunology)

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