Abstract | BACKGROUND:
AKT2 (protein kinase B), an important protein in PI3K signaling pathway, is overexpressed in a variety of malignant tumors. However, in patients with meningiomas, the potential correlation between AKT2 and clinical outcome remains unknown. METHODS: The expression of AKT2 and Ki-67 in meningioma tissues were evaluated immunohistochemically in 94 patients with meningiomas. The correlation of AKT2 immunoreactivity with clinicopathological features and the prognostic value of AKT2 in patients were also analyzed. RESULTS: In this study, we examined the expression of AKT2 in meningiomas and unveiled its possible relationship with the clinical outcome. Immunohistochemical analysis revealed high AKT2 expression in 46 patients (46/94, 48.9%) and low AKT2 expression in the remaining 48 patients (48/94, 51.1%). There was a positive correlation between AKT2 and Ki-67 immunoreactivity (r = 0.35, P = 0.01). Clinicopathological evaluation suggested that AKT2 expression was associated with pathological grade and recurrence (P < 0.05). Univariate and Cox analysis indicated a significant correlation between high levels of AKT2 immunoreactivity and high rates of tumor recurrence (P < 0.05). CONCLUSIONS: We conclude that AKT2 may play an important role in the development of meningioma. High AKT2 labeling index indicates higher grade of meningioma, and therefore AKT2 may be a useful molecular marker for predicting the prognosis of meningioma.
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Authors | Q Wang, S-Y Fan, J Qian, J-Y Wang, Y-C Lu, G-H Hu, C Luo |
Journal | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
(Eur J Surg Oncol)
Vol. 40
Issue 9
Pg. 1056-61
(Sep 2014)
ISSN: 1532-2157 [Electronic] England |
PMID | 24656454
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
- Ki-67 Antigen
- AKT2 protein, human
- Proto-Oncogene Proteins c-akt
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Topics |
- Cohort Studies
- Disease-Free Survival
- Female
- Humans
- Immunohistochemistry
- Ki-67 Antigen
(metabolism)
- Male
- Meningeal Neoplasms
(diagnosis, metabolism, pathology)
- Meningioma
(diagnosis, metabolism, pathology)
- Middle Aged
- Multivariate Analysis
- Neoplasm Grading
- Neoplasm Recurrence, Local
- Neoplasm Staging
- Prognosis
- Proportional Hazards Models
- Proto-Oncogene Proteins c-akt
(metabolism)
- Retrospective Studies
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