Contemporary use of ceftaroline fosamil for the treatment of community-acquired bacterial pneumonia: CAPTURE study experience.

Abstract

The Clinical Assessment Program and Teflaro(®) Utilization Registry (CAPTURE) is a multicenter cohort study designed to collect information on the contemporary use of ceftaroline fosamil in the US. Data collected from 398 evaluable patients with community-acquired bacterial pneumonia (CABP) (mean age 64 years) during the first 18 months of the study are presented. Most patients had co-morbidities (76%; primarily structural lung disease), and ≧2 signs and symptoms of CABP (76%). Overall clinical success was 79% which varied little with ceftaroline fosamil usage (monotherapy vs concurrent therapy; first-line vs second-line therapy). Most patients were discharged home (60%) or to another healthcare facility (35%). These data suggest that ceftaroline, in contemporary clinical use, is an effective antibiotic for the treatment of patients with CABP, including those with significant co-morbidities or who required a change of their prior antibiotic therapy.

• Authors: Ananthakrishnan Ramani, George Udeani, John Evans, Alena Jandourek, Phillip Cole, Alexander Smith, H David Friedland
• Journal: Journal of chemotherapy (Florence, Italy) (J Chemother) Vol. 26 Issue 4 Pg. 229-34 (Aug 2014) ISSN: 1973-9478 [Electronic] England
• PMID: 24650326 (Publication Type: Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Cephalosporins
• ceftaroline fosamil

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anti-Bacterial Agents (therapeutic use)
• Cephalosporins (therapeutic use)
• Cohort Studies
• Community-Acquired Infections (diagnosis, drug therapy, microbiology)
• Escherichia coli (drug effects)
• Female
• Humans
• Klebsiella pneumoniae (drug effects)
• Male
• Microbial Sensitivity Tests
• Middle Aged
• Pneumonia, Bacterial (diagnosis, drug therapy, microbiology)
• Staphylococcus aureus (drug effects)
• Streptococcus pneumoniae (drug effects)
• Young Adult