Abstract | OBJECTIVES: DATA SOURCES: SUMMARY: Many factors play a crucial role in the occurrence of ADRs, some of these are patient related, drug related or socially related factors. Age for instance has a very critical impact on the occurrence of ADRs, both very young and very old patients are more vulnerable to these reactions than other age groups. Alcohol intake also has a crucial impact on ADRs. Other factors are gender, race, pregnancy, breast feeding, kidney problems, liver function, drug dose and frequency and many other factors. The effect of these factors on ADRs is well documented in the medical literature. Taking these factors into consideration during medical evaluation enables medical practitioners to choose the best drug regimen. CONCLUSION: Many factors affect the occurrence of ADRs. Some of these factors can be changed like smoking or alcohol intake others cannot be changed like age, presence of other diseases or genetic factors. Understanding the different effects of these factors on ADRs enables healthcare professionals to choose the most appropriate medication for that particular patient. It also helps the healthcare professionals to give the best advice to patients. Pharmacogenomics is the most recent science which emphasizes the genetic predisposition of ADRs. This innovative science provides a new perspective in dealing with the decision making process of drug selection.
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Authors | Muaed Jamal Alomar |
Journal | Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
(Saudi Pharm J)
Vol. 22
Issue 2
Pg. 83-94
(Apr 2014)
ISSN: 1319-0164 [Print] Saudi Arabia |
PMID | 24648818
(Publication Type: Journal Article, Review)
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