[Organoprotective and metabolic effects of S-amlodipine in patients with arterial hypertension].

Abstract

We compared effects of racemic amlodipine and S-amlodipine in 127 patients with 1-2 degree arterial hypertension (AH) on structural-functional parameters of the left ventricle and brachial artery as well as on characteristics of carbohydrate, lipid, electrolyte, and purine metabolism. Racemic amlodipine was given to 66 and S-amlodipine--to 61 patients. Duration of therapy was 24 weeks. In all patients we observed positive and comparable hypotensive effect while doses of S-amlodipine were significantly lower than those of racemic amlodipine (7.5 +/- 0.8 and 11.6 +/- 1.4 mg/day, respectively, p < 0.01). Monotherapy with S-amlodipine resulted in complete regression of left ventricular hypertrophy in 55% and normalization of left ventricular diastolic function in 62.4% of cases; significant improvement of brachial artery vasomotor function was also observed. In addition treatment with S-amlodipine for 24 weeks in patients with hyperlipidemia led to significant lowering of levels of atherogenic lipoproteins and total cholesterol.

• Authors: B G Iskenderov, S V Saushkina
• Journal: Kardiologiia (Kardiologiia) Vol. 53 Issue 10 Pg. 24-9 ( 2013) ISSN: 0022-9040 [Print] Russia (Federation)
• PMID: 24645552 (Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Calcium Channel Blockers
• Amlodipine

Topics

• Adult
• Amlodipine (therapeutic use)
• Blood Pressure (drug effects)
• Calcium Channel Blockers (therapeutic use)
• Female
• Follow-Up Studies
• Humans
• Hypertension (drug therapy, metabolism, physiopathology)
• Male
• Middle Aged
• Treatment Outcome
• Ventricular Function, Left (drug effects)