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Liver cell carcinoma with orcein-positive granules and no identifiable copper.

Abstract
A liver cell carcinoma removed surgically by partial hepatectomy from a 79-year-old woman contained abundant orcein-positive granules in many tumour cells. The granules were similar to those usually identified as representing copper-associated protein, yet they lacked copper, as demonstrated by negative rhodanine and rubeanic acid stains and energy dispersive X-ray microanalysis.
AuthorsS Shousha, T B Bull
JournalHistopathology (Histopathology) Vol. 13 Issue 4 Pg. 455-8 (Oct 1988) ISSN: 0309-0167 [Print] England
PMID2464537 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Oxazines
  • copper thionein
  • PAcein
  • Copper
  • Metallothionein
Topics
  • Aged
  • Carcinoma, Hepatocellular (metabolism, ultrastructure)
  • Copper (metabolism)
  • Cytoplasmic Granules (metabolism)
  • Female
  • Humans
  • Liver Neoplasms (metabolism, ultrastructure)
  • Metallothionein (metabolism)
  • Oxazines
  • Staining and Labeling

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