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All-trans-retinoic acid promotes iodine uptake via up- regulating the sodium iodide symporter in medullary thyroid cancer stem cells.

Abstract
Recently, the main therapy of medullary thyroid cancer (MTC) is surgical, but by which way there is a poor prognosis with a mean survival of only 5 years. In some cases, some researchers found that it is the medullary thyroid cancer stem cells (MTCSCs) that cause metastasis and recurrence. This study aimed to eradicate MTCSCs through administration of all-trans-retinoic acid (ATRA). Here we demonstrate that MTCSCs possess stem- like properties in serum-free medium. The ABCG2, OCT4 and sodium iodide symporter (NIS) were changed by ATRA. Additionally, we found that ATRA can increase the expression of NIS in vivo. All the data suggested that ATRA could increase the iodine uptake of MTCSCs through NIS.
AuthorsMin Tang, Yan-Li Hou, Qiang-Qiang Kang, Xing-Yue Chen, Li-Qun Duan, Jin Shu, Shao-Lin Li, Xiao-Li Hu, Zhi-Ping Peng
JournalAsian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 15 Issue 4 Pg. 1859-62 ( 2014) ISSN: 2476-762X [Electronic] Thailand
PMID24641421 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • ABCG2 protein, human
  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • ATP-Binding Cassette Transporters
  • Antineoplastic Agents
  • Iodine Radioisotopes
  • Neoplasm Proteins
  • Octamer Transcription Factor-3
  • POU5F1 protein, human
  • Symporters
  • sodium-iodide symporter
  • Tretinoin
  • Iodine
Topics
  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • ATP-Binding Cassette Transporters (genetics)
  • Animals
  • Antineoplastic Agents (pharmacology)
  • Carcinoma, Neuroendocrine
  • Humans
  • Iodine (metabolism)
  • Iodine Radioisotopes (metabolism)
  • Mice
  • Mice, Nude
  • Neoplasm Proteins (genetics)
  • Neoplastic Stem Cells (drug effects, pathology)
  • Octamer Transcription Factor-3 (genetics)
  • Spheroids, Cellular
  • Symporters (genetics)
  • Thyroid Gland (pathology)
  • Thyroid Neoplasms (pathology)
  • Tretinoin (pharmacology)
  • Tumor Cells, Cultured

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