Off-label uses of topical vitamin D in dermatology: a systematic review.

Abstract

BACKGROUND:

Topical vitamin D is approved by the US Food and Drug Administration for the treatment of psoriasis but is also used off-label in the treatment of a variety of cutaneous diseases despite a lack of evidence-based guidelines.

OBJECTIVE:

The objective of this study was to provide evidence-based clinical guidelines for the off-label use of topical vitamin D in the treatment of dermatologic disease.

METHODS:

A systematic literature review was conducted via the MEDLINE, Embase, and CENTRAL databases for off-label uses of topical vitamin D analogues in the treatment of dermatologic disease other than psoriasis. The data were synthesized, and evidence-based recommendations were rendered according to the highest level of evidence available.

RESULTS:

A total of 165 articles met the inclusion criteria. A moderate to strong recommendation was given for the use of topical vitamin D in combination with corticosteroids and phototherapy in vitiligo and as monotherapy for various ichthyoses, morphea, pityriasis alba, prurigo nodularis, and polymorphous light eruption. There is evidence showing that topical vitamin D is ineffective in the treatment of actinic keratosis, seborrheic keratosis, lichen planus, seborrheic dermatitis, alopecia areata, chemotherapy-induced alopecia, and hypertrophic scars.

CONCLUSION:

Topical vitamin D analogues have an important role in the off-label treatment of dermatologic disease, but higher quality studies are still required.

• Authors: Heidi Wat, Marlene Dytoc
• Journal: Journal of cutaneous medicine and surgery (J Cutan Med Surg) 2014 Mar-Apr Vol. 18 Issue 2 Pg. 91-108 ISSN: 1203-4754 [Print] United States
• PMID: 24636434 (Publication Type: Journal Article, Review, Systematic Review)

Chemical References

• Vitamin D

Topics

• Administration, Topical
• Dermatology (methods)
• Humans
• Off-Label Use
• Skin Diseases (drug therapy)
• Vitamin D (administration & dosage, adverse effects)