Analysis of YKL-40 acute-phase protein and interleukin-6 levels in periodontal disease.

Abstract

BACKGROUND:

YKL-40, a new acute-phase protein, is shown to be elevated in inflammatory diseases, such as rheumatoid arthritis, type 2 diabetes mellitus, and coronary artery diseases. However, there is no data indicating a relationship between YKL-40 and periodontal disease. Interleukin-6 (IL-6) is the major regulator of acute-phase protein synthesis and one of the most studied inflammatory markers in periodontal disease. The purpose of the present study is to evaluate YKL-40 and IL-6 levels in gingival crevicular fluid (GCF) and serum of patients with periodontal disease and healthy individuals.

METHODS:

Periodontally healthy individuals (n = 15), patients with gingivitis (n = 15), and patients with severe chronic periodontitis (CP) (n = 15) without any systemic disease were included in the study. Clinical measurements were recorded; GCF and blood samples were obtained from each participant. GCF and serum YKL-40 and IL-6 levels were analyzed by enzyme-linked immunosorbent assay. Statistical analysis was performed by parametric and non-parametric tests.

RESULTS:

Total amounts of YKL-40 and IL-6 in GCF as well as serum YKL-40 and IL-6 levels were significantly higher in patients with gingivitis and CP compared with healthy controls (P <0.01). YKL-40 levels in GCF and serum as well as serum IL-6 levels were significantly higher in patients with CP compared with patients with gingivitis (P <0.01).

CONCLUSIONS:

YKL-40 levels in GCF as well as serum YKL-40 and IL-6 levels increased from gingivitis to periodontitis. Within the limits of the present study, the YKL-40 molecule might be a potential novel inflammatory marker of periodontal disease.

• Authors: Zeynep Pinar Keles, Gonca Cayir Keles, Bahattin Avci, Burcu Ozkan Cetinkaya, Gulnur Emingil
• Journal: Journal of periodontology (J Periodontol) Vol. 85 Issue 9 Pg. 1240-6 (Sep 2014) ISSN: 1943-3670 [Electronic] United States
• PMID: 24635545 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acute-Phase Proteins
• Adipokines
• Autoantigens
• Biomarkers
• CHI3L1 protein, human
• Chitinase-3-Like Protein 1
• IL6 protein, human
• Inflammation Mediators
• Interleukin-6
• Lectins

Topics

• Acute-Phase Proteins (analysis)
• Adipokines (analysis, blood)
• Adult
• Alveolar Bone Loss (immunology)
• Autoantigens (analysis, blood)
• Biomarkers (analysis, blood)
• Chitinase-3-Like Protein 1
• Chronic Periodontitis (blood, immunology)
• Dental Plaque Index
• Female
• Gingival Crevicular Fluid (immunology)
• Gingivitis (blood, immunology)
• Humans
• Inflammation Mediators (analysis)
• Interleukin-6 (analysis, blood)
• Lectins (analysis, blood)
• Male
• Middle Aged
• Periodontal Attachment Loss (immunology)
• Periodontal Index
• Periodontal Pocket (immunology)