Abstract | CONTEXT: OBJECTIVE: To investigate enzyme inhibitory activity against α- glucosidase and 15-lipoxygenase (15-LO) and toxicity against brine shrimp of extracts and compounds from T. macroptera leaves. MATERIALS AND METHODS: RESULTS: CONCLUSION: Inhibition of α- glucosidase in the gastrointestinal tract may be a rationale for the medicinal use of T. macroptera leaves against diabetes in traditional medicine in Mali. The plant extracts and its constituents show strong inhibition of the peroxidative enzyme 15-LO.
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Authors | Anh Thu Pham, Karl Egil Malterud, Berit Smestad Paulsen, Drissa Diallo, Helle Wangensteen |
Journal | Pharmaceutical biology
(Pharm Biol)
Vol. 52
Issue 9
Pg. 1166-9
(Sep 2014)
ISSN: 1744-5116 [Electronic] England |
PMID | 24635511
(Publication Type: Journal Article)
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Chemical References |
- Glycoside Hydrolase Inhibitors
- Lipoxygenase Inhibitors
- Plant Extracts
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Topics |
- Animals
- Artemia
- Glycoside Hydrolase Inhibitors
(isolation & purification, pharmacology, toxicity)
- Inhibitory Concentration 50
- Lipoxygenase Inhibitors
(isolation & purification, pharmacology, toxicity)
- Mali
- Medicine, African Traditional
- Plant Extracts
(administration & dosage, pharmacology, toxicity)
- Plant Leaves
- Terminalia
(chemistry)
- Toxicity Tests
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